Observation of the Efficacy of Dexamethasone Administration via Different Routes in the Treatment of Severe Sudden Deafness
Abstract
sudden deafness. Methods: Inpatients with severe sudden deafness (average hearing threshold > 60 dBHL) who were treated in the Department of Otorhinolaryngology of Tianshui 407 Hospital from July 2023 to March 2025 were selected as the research subjects, regardless of
gender. Those with primary diseases were excluded. The patients were randomly divided into three groups and received subperiosteal injection behind the ear, endoscopic intratympanic injection, and combined subperiosteal injection behind the ear and endoscopic intratympanic
injection of dexamethasone respectively. The efficacy of the three different local injection routes on hearing restoration and the influencing
factors were observed. Results: Among the 45 enrolled patients, there were significant differences in the efficacy of different local injection
routes. The total effective rate of the postauricular group was 0, that of the intratympanic group was 57.9%, and that of the combined group
was 61.1%. The total effective rate of the combined postauricular and intratympanic injection group was significantly higher than that of the
postauricular injection group. The total effective rate of the combined group was slightly higher than that of the intratympanic injection group,
and there was no significant difference in the total effective rate between the intratympanic injection group and the combined postauricular
and intratympanic injection group. During the study, some patients experienced pain, and no other complications such as tympanic membrane
perforation and middle ear infection occurred. Moreover, the gender, ear side, and age of the research subjects had no correlation with the efficacy of sudden deafness. Conclusion: Local combined postauricular and intratympanic injection has a good efficacy in the treatment of severe sudden deafness with full - frequency decline. Compared with local postauricular injection, intratympanic injection can also significantly
improve the efficacy of severe sudden deafness. The local injection route is simple and safe, and no serious adverse events occur. This study
provides a basis for the treatment of different types of inner ear diseases with different administration routes and also lays a foundation for the
further development of more reasonable individualized treatment plans.
Keywords
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DOI: http://dx.doi.org/10.70711/aitr.v2i8.6636
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