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Analysis of Eplerenone Synthesis Process

Zhenping Shao, Rong Wang, Lijiang Mao

Abstract


Eplerenone, a selective aldosterone receptor antagonist, is primarily used to treat hypertension and heart failure. This paper provides
a detailed analysis of the synthesis process of eplerenone, focusing on synthesis routes, reaction conditions, catalyst selection, yield, and purity control. The technical details discussed aim to support theoretical foundations and practical guidance for industrial-scale production of
this drug.

Keywords


Eplerenone; Aldosterone receptor antagonist; Industrial-scale production

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References


[1] Chen Yijun, Sui Zhihong, Jin Danni. Research on a New Synthesis Process of Eplerenone[J]. Chemical Production and Technology,

2022, 28(06): 11-13+45+8.

[2] Yu Xuchao, Ye Youzhi, Jiang Jianwu. Research Progress on Eplerenone Synthesis Process[J]. Zhejiang Chemical Industry, 2022, 53(09):

12-17.

[3] Wan Jinjin, Li Juan, Zeng Hui, et al. Meta-analysis of the efficacy and safety of spironolactone or eplerenone in patients with primary

aldosteronism[J]. Chongqing Medicine, 2023, 52(04): 552-557.


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