pisco_log
banner

Application and Optimization of Novel Asymmetric Catalysts in Drug Synthesis

Henry Jiaheng Lyu

Abstract


This study aims to develop a novel asymmetric catalyst and explore its application and optimization in drug synthesis. By designing specific organometallic frameworks and optimizing the catalytic active centers, the study successfully enhanced the efficiency and selectivity of drug synthesis. The experiments included measuring catalytic efficiency, evaluating product selectivity, and testing the recyclability of the catalyst. The results indicate that the novel catalyst not only excels in improving synthesis efficiency but also demonstrates excellent selectivity and high potential for reuse. The study also investigates various factors affecting catalyst performance and provides constructive suggestions for future research directions.

Keywords


Asymmetric catalyst; Drug synthesis; Catalytic efficiency; Selectivity; Organometallic framework

Full Text:

PDF

Included Database


References


Gao, Xinyue. "Synthesis of Novel Chiral Nitrogen-Oxygen Catalysts and Their Application in Asymmetric Hydrosilylation Reactions"

[D]. Hebei University, 2021.

Zhang, Min. "Design, Synthesis of Novel C_2 Axial Chiral Amide Catalysts, and Their Application in Asymmetric Cascade Reactions"

[D]. Guizhou Normal University, 2022.

Sui, Xuelin. "Synthesis and Application of Novel Coordination Polymer Catalysts and Research on Asymmetric Structures in Olefin Polymerization Catalyst Design" [D]. University of Science and Technology of China, 2018.

Zhu H, Xu T, Qiu C, et al.Synthesis and optimization of novel allylated mono-carbonyl analogs of curcumin (MACs) act as potent antiinflammatory agents against LPS-induced acute lung injury (ALI) in rats[J].European Journal of Medicinal Chemistry, 2016.

Gurjar M K, Hotha S, Murugaiah A M S.Role of Asymmetric Catalysts in Chiral Drug Synthesis[J].ChemInform, 2010, 33(44):259-259.

Brotherton-Pleiss C E, Dillon M P, Ford A P D W, et al.Discovery and optimization of RO-85, a novel drug-like, potent, and selective

P2X3 receptor antagonist.[J].Bioorganic & Medicinal Chemistry Letters, 2010, 20(3):1031-1036.




DOI: http://dx.doi.org/10.18686/frim.v2i6.4688

Refbacks

  • There are currently no refbacks.