万彩网·首页欢迎您

pisco_log

Open Journal Systems

User

Language

Journal Content

Font Size

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All

Geological and Mining Engineering

Geological and Mining Engineering (GME), published by Scineer Publishing PTE. LTD, is an open-access journal. GME is devoted to publish geological and mining engineering related articles in the form of original papers, review papers and case studies. It also provides a platform for scholars to exchange the latest information in the related fields and aim to promote the research on geological and mining engineering throughout the world. GME welcomes all original

ISSN: 3029-1887(P)

3029-2034(O)

View Journal Current Issue Register

Food Safety and Quality

Food Safety and Quality (FSQ), published by Scineer Publishing PTE. LTD, is an open-access journal. FSQ is devoted to publish food safety and quality related articles in the form of original papers, review papers and case studies. It also provides a platform for scholars to exchange the latest information in the related fields and aim to promote the research on food safety and quality throughout the world. FSQ welcomes all original manuscripts that do not be published in any other journals.

ISSN: 3029-2115(P)

3029-2123(O)

View Journal Current Issue Register

Hydraulic Engineering and Power Research

Hydraulic Engineering and Power Research (HEPR), published by Scineer Publishing PTE. LTD, is an open-access journal. HEPR is devoted to publish hydraulic engineering and power related articles in the form of original papers, review papers and case studies. It also provides a platform for scholars to exchange the latest information in the related fields and aim to promote the research on hydraulic engineering and power throughout the world. HEPR welcomes all original manuscripts that do not be published in any other journals.Â

Â Â Â

Â Â Â Â ISSN: 3029-2158(P)

Â Â Â Â Â Â Â Â Â 3029-2166(O)

Â Â Â Â Â Â Â

View Journal Current Issue Register

Medical and Health Research

Medical and Health Research (MHR), published by Scineer Publishing PTE. LTD, is an open-access journal. MHR is devoted to publish medicine related articles in the form of original papers, review papers and case studies. It also provides a platform for scholars to exchange the latest information in the related fields and aim to promote the research on medicine throughout the world. MHR welcomes all original manuscripts that do not be published in any other journals.Â

Â Â Â

Â Â Â Â ISSN: 3029-2190(P)

Â Â Â Â Â Â Â Â Â 3029-2204(O)

Â Â Â Â Â Â Â

View Journal Current Issue Register

Practical Medical Research

Practical Medical Research (PMR), published by Scineer Publishing PTE. LTD, is an open-access journal. PMR is devoted to publish medicine related articles in the form of original papers, review papers and case studies. It also provides a platform for scholars to exchange the latest information in the related fields and aim to promote the research on medicine throughout the world. PMR welcomes all original manuscripts that do not be published in any other journals.Â

Â Â Â Â

Â Â Â Â ISSN: 3029-2085(P)

Â Â Â Â Â Â Â Â Â Â 3029-2093(O)

Â Â Â Â Â Â Â

View Journal Current Issue Register

Forum on Research and Innovation Management

Forum on Research and Innovation Management (FRIM), published by Scineer Publishing PTE. LTD, is an open-access journal. FRIM is devoted to publish research and innovation management related articles in the form of original papers, review papers and case studies. It also provides a platform for scholars to exchange the latest information in the related fields and aim to promote the research on research and innovation management throughout the world. FRIM welcomes all original manuscripts that do not be published in any other journals.Â

Â Â Â Â

Â Â Â Â ISSN: 3029-1933(P)

Â Â Â Â Â Â Â Â Â 3029-1984(O)

Â Â Â Â Â Â Â

View Journal Current Issue Register

Construction Safety Technology and Management

Construction Safety Technology and Management (CSTM), published by Scineer Publishing PTE. LTD, is an open-access journal. CSTM is devoted to publish construction safety technology and management related articles in the form of original papers, review papers and case studies. It also provides a platform for scholars to exchange the latest information in the related fields and aim to promote the research on construction safety technology and management throughout the world. CSTM welcomes all original manuscripts that do not be published in any other journals.Â

Â Â Â

Â Â Â Â Â ISSN: 3029-2069(P)

Â Â Â Â Â Â Â Â Â Â Â 3029-2077(O)

Â Â Â Â Â Â Â

View Journal Current Issue Register

Industrial Technology Research

Industrial Technology Research (ITR), published by Scineer Publishing PTE. LTD, is an open-access journal. ITR is devoted to publish industrial technology related articles in the form of original papers, review papers and case studies. It also provides a platform for scholars to exchange the latest information in the related fields and aim to promote the research on industrial technology throughout the world. ITR welcomes all original manuscripts that do not be published in any other journals.

Â Â Â Â

Â Â Â Â ISSN: 3029-1895(P)

Â Â Â Â Â Â Â Â Â Â 3029-2026(O)

Â Â Â Â Â Â Â

View Journal Current Issue Register

Environmental Protection and Health

Environmental Protection and Health (EPH), published by Scineer Publishing PTE. LTD, is an open-access journal. EPH is devoted to publish environmental protection and health related articles in the form of original papers, review papers and case studies. It also provides a platform for scholars to exchange the latest information in the related fields and aim to promote the research on environmental protection and health throughout the world. EPH welcomes all original manuscripts that do not be published in any other journals.Â

Â Â

Â Â Â Â ISSN: 3029-1909(P)

Â Â Â Â Â Â Â Â Â 3029-2018(O)

Â Â Â Â Â Â Â

View Journal Current Issue Register

Artificial Intelligence Technology Research

Artificial Intelligence Technology Research (AITR), published by Scineer Publishing PTE. LTD, is an open-access journal. AITR is devoted to publish artificial intelligence technology related articles in the form of original papers, review papers and case studies. It also provides a platform for scholars to exchange the latest information in the related fields and aim to promote the research on artificial intelligence technology throughout the world. AITR welcomes all original manuscripts that do not be published in any other journals.Â

Â Â Â Â ISSN: 3029-1968(O)

Â Â Â Â Â Â Â Â Â 3029-195X(P)
Â Â Â Â Â

Â Â

View Journal Current Issue Register

Curriculum Learning and Exploration

Curriculum Learning and Exploration (CLE), published by Scineer Publishing PTE. LTD, is an open-access journal. CLE is devoted to publish curriculum related articles in the form of original papers, review papers and case studies. It also provides a platform for scholars to exchange the latest information in the related fields and aim to promote the research on curriculum throughout the world. CLE welcomes all original manuscripts that do not be published in any other journals.Â

Â Â Â Â ISSN: 3029-1976(O)

Â Â Â Â Â Â Â Â Â 3029-1941(P)
Â Â Â Â Â Â Â

View Journal Current Issue Register

Evaluation of Educational Research

Evaluation of Educational Research (EER), published by Scineer Publishing PTE. LTD, is an open-access journal. EER is devoted to publish education related articles in the form of original papers, review papers and case studies. It also provides a platform for scholars to exchange the latest information in the related fields and aim to promote the research on education throughout the world. EER welcomes all original manuscripts that do not be published in any other journals.

Â Â Â Â ISSN: 3029-1992(O)

Â Â Â Â Â Â Â Â Â 3029-1925(P)
Â Â Â Â Â Â Â

View Journal Current Issue Register

World Education Forum

World Education Forum (WEF), published by Scineer Publishing PTE. LTD, is an open-access journal. WEF is devoted to publish education related articles in the form of original papers, review papers and case studies. It also provides a platform for scholars to exchange the latest information in the related fields and aim to promote the research on education throughout the world. WEF welcomes all original manuscripts that do not be published in any other journals.

Â Â Â Â ISSN: 3029-214X(O)

Â Â Â Â Â Â Â Â Â 3029-2131(P)

Â Â Â Â Â Â Â

View Journal Current Issue Register

New Explorations in Education and Teaching

New Explorations in Education and Teaching (NEET), published by Scineer Publishing PTE. LTD, is an open-access journal. NEET is devoted to publish education related articles in the form of original papers, review papers and case studies. It also provides a platform for scholars to exchange the latest information in the related fields and aim to promote the research on education throughout the world. NEET welcomes all original manuscripts that do not be published in any other journals.Â

Â Â Â Â ISSN: 3029-200X(O)

Â Â Â Â Â Â Â Â Â 3029-1917(P)

Â Â Â Â Â Â Â

View Journal Current Issue Register

Modern Economic Management Forum

Â

Modern Economic Management Forum (MEMF), published by Scineer Publishing PTE. LTD, is an open-access journal. MEMF is devoted to publish modern economic management related articles in the form of original papers, review papers and case studies. It also provides a platform for scholars to exchange the latest information in the related fields and aim to promote the research on economic management throughout the world. MEMF welcomes all original manuscripts that do not be published in any other journals.Â

Â Â Â Â ISSN: 3029-2182(O)

Â Â Â Â Â Â Â Â Â 3029-2174(P)

Â Â Â Â Â Â Â

View Journal Current Issue Register

Research and Commentary on Humanities and Arts

Research and Commentary on Humanities and ArtsÂ (RCHA), published by Scineer Publishing PTE. LTD, is an open-access journal. RCHA is devoted to publish humanities and arts related articles in the form of original papers, review papers and case studies. It also provides a platform for scholars to exchange the latest information in the related fields and aim to promote the research on humanities and arts throughout the world. RCHA welcomes all original manuscripts that do not be published in any other journals.Â

Â

Â Â Â

Â Â Â Â Â Â ISSN: 3029-2050(O)

Â Â Â Â Â Â Â Â Â Â Â 3029-2042(P)

Â Â Â Â Â Â Â

View Journal Current Issue Register

Scineer Publishing is a publisher of open access journals. Covering various disciplines and promoting interdisciplinary development, Scineer Publishing adheres to a principle of respecting academics, and publishes insightful and rigorous academic research contents.

12 Eu Tong Sen Street, #07-168, Singapore 059819

E-mail: scineerpub@126.com

Copyright © 2023 Scineer Publishing Pte. Ltd.

Investigating the Relationship between Crocin from Gardenia and Breast Cancer Based on Network Pharmacology

Xinyu Jiang, Yang Li, Que yang*

Abstract

Objective: To explore the mechanisms of action of crocin from Gardenia in treating breast cancer through network pharmacology.
Methods: Potential action targets of crocin were obtained from the TCMSP, Uniprot, and SwissTargetPrediction databases. Breast cancer
genes were retrieved from the GeneCards database. The intersection genes were identified using the Venny tool on the Microbioinformatics
platform and subsequently imported into the String database for analysis. A protein-protein interaction (PPI) network was constructed, and
GO functional enrichment analysis and KEGG pathway enrichment analysis were performed using the DAVID database. The “componentdisease-common gene” network was visualized using Cytoscape 3.10.2 software. Results: Key targets for crocin in treating breast cancer
included HSP90AA1, STAT3, and ESR1. Major pathways involved in treatment included cancer pathways, resistance to epidermal growth
factor receptor (EGFR) tyrosine kinase inhibitors, chemical carcinogenesis—receptor activation, prolactin signaling pathways, estrogen signaling pathways, endocrine resistance, and HIF-1 signaling pathways. Conclusion: Crocin exerts therapeutic effects on breast cancer through
multiple targets and pathways.

Keywords

Gardenia; Crocin; Hyperlipidemia; Network Pharmacology

Full Text:

PDF

Included Database

References

[1] Zheng RS, Chen R, Han BF, et al. [Cancer incidence and mortality in China, 2022][J]. Zhonghua Zhong Liu Za Zhi [Chinese Journal of

Oncology], 2024, 46(3): 221-231.

[2] Zhou BD, Huang ST. Effect of gardenia gardenia on hyperlipidemia based on network pharmacology [J]. Journal of Yichun College (12):

9-13, 58. (in Chinese)

[3] Fei Y, Zhu DP, Liu F, et al. Effects of gardenia gardenia on blood glucose and blood lipid in STZ-induced type 2 diabetic rats [J]. Pharmacology and Clinic of Chinese Medicine (6): 49-52. (in Chinese)

[4] Zheng L, Zhang WS. Research progress of modern pharmacological effects of Gardenia gardenia [J]. Global Chinese Medicine (10):

1813-1817. (in Chinese)

[5] J E, GL A, M C P, et al. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in

vitro[J/OL]. Cancer letters, 1996, 100(1-2)[2024-10-14]. https://pubmed.ncbi.nlm.nih.gov/8620447/.

[6] Song YN, Wang Y, Zheng YH, 等. Crocins: A comprehensive review of structural characteristics, pharmacokinetics and therapeutic

effects[J]. Fitoterapia, 2021, 153: 104969.

[7] T O, H S, K M, et al.. Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo[J/OL]. Biochimica et biophysica acta, 2007, 1770(4)[2024-10-14]. https://pubmed.ncbi.nlm.nih.gov/17215084/.

[8] Liu FZ, Li YB, Li M, et al. Study on the mechanism of pharmacological action of saffron components of Gardenia jasminoides from

Zhejiang Province based on Network pharmacology [J]. Chinese Herbal Medicine (8): 1873-1879. (in Chinese)

[9] Jiang C Y. Experimental study on the effect of HSP90AA1 and its inhibitors on the proliferation and migration of gastric malignant tumors [D/OL]. China Medical University, 2022[2024-10-23]. https://doi.org/10.27652/d.cnki.gzyku.2021.000887.

[10] HU J, CHEN K, HONG F, et al. METTL3 facilitates stemness properties and tumorigenicity of cancer stem cells in hepatocellular carcinoma through the SOCS3/JAK2/STAT3 signaling pathway.[J/OL]. Cancer Gene Therapy, 2023[2024-10-23]. https://www.nature.com/

articles/s41417-023-00697-w.

[11] HERZOG S K, FUQUA S A W. ESR1 mutations and therapeutic resistance in metastatic breast cancer: progress and remaining

challenges[J]. British Journal of Cancer, 2022, 126(2): 174-186.

[12] Xie SH, Gao ZC, Zhang W et al. Research progress of acquired drug resistance and epidermal growth factor receptor targeted therapy

tolerance mechanism in non-small cell lung cancer [J]. Pharmacovigilance in China (10): 1081-1086. (in Chinese)

[13] Wu Q, Jin NZ, Yu J, et al. Effect of soybean isoflavone total extract on ovariectomized nude mice transplanted with estrogen-dependent

breast cancer cells [J]. Chinese Science Bulletin (22): 2754-2759. (in Chinese)

[14] Chen TX, Yang LW, Chen SB, et al. Hypoxic inducible factor HIF-1A regulates GLUT3 expression and promotes glioma proliferation [J/

OL]. Journal of Hainan Medical College, 2024[2024-10-23]. https://doi.org/10.13210/j.cnki.jhmu.20240830.005.

DOI: http://dx.doi.org/10.70711/pmr.v2i3.5464

Refbacks

There are currently no refbacks.

Scineer Publishing is a publisher of open access journals. Covering various disciplines and promoting interdisciplinary development, Scineer Publishing adheres to a principle of respecting academics, and publishes insightful and rigorous academic research contents.

12 Eu Tong Sen Street, #07-168, Singapore 059819

E-mail: scineerpub@126.com

Copyright © 2023 Scineer Publishing Pte. Ltd.