Investigating the Relationship between Crocin from 
Gardenia and Breast Cancer Based on Network Pharmacology

Xinyu Jiang; Yang Li; Que yang*

doi:10.70711/pmr.v2i3.5464

Investigating the Relationship between Crocin from Gardenia and Breast Cancer Based on Network Pharmacology

Xinyu Jiang, Yang Li, Que yang*

Abstract

Objective: To explore the mechanisms of action of crocin from Gardenia in treating breast cancer through network pharmacology.
Methods: Potential action targets of crocin were obtained from the TCMSP, Uniprot, and SwissTargetPrediction databases. Breast cancer
genes were retrieved from the GeneCards database. The intersection genes were identified using the Venny tool on the Microbioinformatics
platform and subsequently imported into the String database for analysis. A protein-protein interaction (PPI) network was constructed, and
GO functional enrichment analysis and KEGG pathway enrichment analysis were performed using the DAVID database. The componentdisease-common gene network was visualized using Cytoscape 3.10.2 software. Results: Key targets for crocin in treating breast cancer
included HSP90AA1, STAT3, and ESR1. Major pathways involved in treatment included cancer pathways, resistance to epidermal growth
factor receptor (EGFR) tyrosine kinase inhibitors, chemical carcinogenesisreceptor activation, prolactin signaling pathways, estrogen signaling pathways, endocrine resistance, and HIF-1 signaling pathways. Conclusion: Crocin exerts therapeutic effects on breast cancer through
multiple targets and pathways.

Keywords

Gardenia; Crocin; Hyperlipidemia; Network Pharmacology

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References

[1] Zheng RS, Chen R, Han BF, et al. [Cancer incidence and mortality in China, 2022][J]. Zhonghua Zhong Liu Za Zhi [Chinese Journal of

Oncology], 2024, 46(3): 221-231.

[2] Zhou BD, Huang ST. Effect of gardenia gardenia on hyperlipidemia based on network pharmacology [J]. Journal of Yichun College (12):

9-13, 58. (in Chinese)

[3] Fei Y, Zhu DP, Liu F, et al. Effects of gardenia gardenia on blood glucose and blood lipid in STZ-induced type 2 diabetic rats [J]. Pharmacology and Clinic of Chinese Medicine (6): 49-52. (in Chinese)

[4] Zheng L, Zhang WS. Research progress of modern pharmacological effects of Gardenia gardenia [J]. Global Chinese Medicine (10):

1813-1817. (in Chinese)

[5] J E, GL A, M C P, et al. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in

vitro[J/OL]. Cancer letters, 1996, 100(1-2)[2024-10-14]. https://pubmed.ncbi.nlm.nih.gov/8620447/.

[6] Song YN, Wang Y, Zheng YH, ?. Crocins: A comprehensive review of structural characteristics, pharmacokinetics and therapeutic

effects[J]. Fitoterapia, 2021, 153: 104969.

[7] T O, H S, K M, et al.. Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo[J/OL]. Biochimica et biophysica acta, 2007, 1770(4)[2024-10-14]. https://pubmed.ncbi.nlm.nih.gov/17215084/.

[8] Liu FZ, Li YB, Li M, et al. Study on the mechanism of pharmacological action of saffron components of Gardenia jasminoides from

Zhejiang Province based on Network pharmacology [J]. Chinese Herbal Medicine (8): 1873-1879. (in Chinese)

[9] Jiang C Y. Experimental study on the effect of HSP90AA1 and its inhibitors on the proliferation and migration of gastric malignant tumors [D/OL]. China Medical University, 2022[2024-10-23]. https://doi.org/10.27652/d.cnki.gzyku.2021.000887.

[10] HU J, CHEN K, HONG F, et al. METTL3 facilitates stemness properties and tumorigenicity of cancer stem cells in hepatocellular carcinoma through the SOCS3/JAK2/STAT3 signaling pathway.[J/OL]. Cancer Gene Therapy, 2023[2024-10-23]. https://www.nature.com/

articles/s41417-023-00697-w.

[11] HERZOG S K, FUQUA S A W. ESR1 mutations and therapeutic resistance in metastatic breast cancer: progress and remaining

challenges[J]. British Journal of Cancer, 2022, 126(2): 174-186.

[12] Xie SH, Gao ZC, Zhang W et al. Research progress of acquired drug resistance and epidermal growth factor receptor targeted therapy

tolerance mechanism in non-small cell lung cancer [J]. Pharmacovigilance in China (10): 1081-1086. (in Chinese)

[13] Wu Q, Jin NZ, Yu J, et al. Effect of soybean isoflavone total extract on ovariectomized nude mice transplanted with estrogen-dependent

breast cancer cells [J]. Chinese Science Bulletin (22): 2754-2759. (in Chinese)

[14] Chen TX, Yang LW, Chen SB, et al. Hypoxic inducible factor HIF-1A regulates GLUT3 expression and promotes glioma proliferation [J/

OL]. Journal of Hainan Medical College, 2024[2024-10-23]. https://doi.org/10.13210/j.cnki.jhmu.20240830.005.

DOI: http://dx.doi.org/10.70711/pmr.v2i3.5464

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