Research Progress of Notch3 in Glioblastoma
Abstract
apoptosis. The Notch family includes four receptors (Notch1-4), among which Notch3 plays a key role in various malignant tumors. Glioblastoma (GBM) is the most malignant tumor in the central nervous system, due to its high malignancy, easy recurrence, tolerance to conventional
treatment, and currently unsatisfactory treatment outcomes. Therefore, it is necessary to find more effective treatment strategies targeting
GBM. In recent years, an increasing number of studies have shown that Notch3 plays an important tumorigenic role in gliomas, especially
glioblastoma (GBM). Therefore, Notch3 may serve as a new target for the treatment of glioblastoma.
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[1] Taillibert S, Delattre JY: Metastatic tumors of the nervous system. Journal of neuro-oncology 2005, 75(1): 1-3.
[2] Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison
DW: The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta neuropathologica 2016, 131(6): 803-820.
[3] Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G et al: The
2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro-oncology 2021, 23(8): 1231-1251.
[4] Simpson JR, Horton J, Scott C, Curran WJ, Rubin P, Fischbach J, Isaacson S, Rotman M, Asbell SO, Nelson JS et al: Influence of location and extent of surgical resection on survival of patients with glioblastoma multiforme: results of three consecutive Radiation
Therapy Oncology Group (RTOG) clinical trials. International journal of radiation oncology, biology, physics 1993, 26(2): 239-244.
[5] Kelly PJ, Daumas-Duport C, Kispert DB, Kall BA, Scheithauer BW, Illig JJ: Imaging-based stereotaxic serial biopsies in untreated
intracranial glial neoplasms. Journal of neurosurgery 1987, 66(6): 865-874.
[6] Burger PC, Heinz ER, Shibata T, Kleihues P: Topographic anatomy and CT correlations in the untreated glioblastoma multiforme.
Journal of neurosurgery 1988, 68(5): 698-704.
[7] Aburjania Z, Jang S, Whitt J, Jaskula-Stzul R, Chen H, Rose JB: The Role of Notch3 in Cancer. The oncologist 2018, 23(8): 900-911.
[8] Aldape K, Zadeh G, Mansouri S, Reifenberger G, von Deimling A: Glioblastoma: pathology, molecular mechanisms and markers.
Acta neuropathologica 2015, 129(6): 829-848.
[9] Kanderi T, Gupta V: Glioblastoma Multiforme. In: StatPearls. edn. Treasure Island (FL) ineligible companies. Disclosure: Vikas Gupta
declares no relevant financial relationships with ineligible companies.: StatPearls Publishing. Copyright 2023, StatPearls Publishing
LLC.; 2023.
[10] Alifieris C, Trafalis DT: Glioblastoma multiforme: Pathogenesis and treatment. Pharmacology & therapeutics 2015, 152:63-82.
DOI: http://dx.doi.org/10.70711/pmr.v2i3.5470
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