Advances in the Study of the Inflammatory Association 
Between Obstructive Sleep Apnea and Coronary Heart 
Disease

Chengyou Li; Mingsheng Lei; Yurou Zhang; Jianhui Zhang; Enping Li; Yanping Zhou; Ying Liu

doi:10.70711/pmr.v2i3.5474

Advances in the Study of the Inflammatory Association Between Obstructive Sleep Apnea and Coronary Heart Disease

Chengyou Li, Mingsheng Lei, Yurou Zhang, Jianhui Zhang, Enping Li, Yanping Zhou, Ying Liu

Abstract

This study examines the inflammatory association between obstructive sleep apnea (OSA) and coronary artery disease (CAD),
highlighting the central role of the inflammatory response. Apnea and hypoxemia during sleep in patients with OSA activate inflammatory
cytokines, such as tumor necrosis factor-alpha and interleukin-6, promoting vascular endothelial damage and plaque formation. Metabolic
dysfunction induced by intermittent hypoxia, particularly insulin resistance and abnormal lipid metabolism, enhances the development of
coronary atherosclerosis. Furthermore, OSA-induced sympathetic hyperactivation elevates the blood pressure and accelerates the heart rate,
further exacerbating the risk of CAD. Therefore, controlling the inflammatory response in patients with OSA is essential for alleviating the
risk of coronary heart disease.

Keywords

Obstructive Sleep Apnea; Coronary artery disease; Inflammatory response

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DOI: http://dx.doi.org/10.70711/pmr.v2i3.5474

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