The COVID-19 pandemic has brought unprecedented economic, social, and public health challenges. Studies have shown that the
lung microbial community changes in COVID-19 patients. The microbiota impacts metabolism, inflammation, and immune response through
various mechanisms, playing a critical regulatory role in the pathophysiological process of the organism. Disruptions in the lung’s microbiota
may impact the severity and clinical prognosis of COVID-19 by influencing the immune system. Currently, the specific action mechanism of
the lung microbiota in COVID-19 is unclear, and we lack reliable indicators to predict and evaluate clinical outcomes. This review explores
the research on the lung microbiota in COVID-19 patients, hoping to identify new approaches for clinical diagnosis and treatment.

COVID-19; Lung microbiota; Dysbiosis; Immune imbalance; Review

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