Bear Bile and Its Main Bile Acid Active Ingredients in 
the Treatment of Ischemic Stroke

Zhangwei Chen*; Yuchen Jin; Danni Li

doi:10.70711/pmr.v2i4.6105

Bear Bile and Its Main Bile Acid Active Ingredients in the Treatment of Ischemic Stroke

Zhangwei Chen*, Yuchen Jin, Danni Li

Abstract

Ischemic stroke stands as a significant worldwide illness characterized by intricate origins, a high rate of recurrence, and a high
mortality rate. Bear bile, a traditional Chinese medicinal practice, frequently acts as an anti-inflammatory, anti-apoptotic, and anti-oxidative
agent in the clinical management of cardiovascular and cerebrovascular disorders. Bear bile primarily consists of bile acids, such as taurocholic acid (TUDCA), taurodeoxycholic acid (TCTCA), ursodeoxycholic acid (UDCA), and goosenodeoxycholic acid (CDCA), known for
their diverse and varied therapeutic approaches in treating ischemic stroke. Currently, bear bile, along with its primary active components, has
undergone artificial industrialization, offering wide-ranging potential in treating diseases of the central system, thanks to the ability of its key
bile acid components to penetrate the blood-brain barrier. Considering cell damage and recovery post-ischemic stroke, our review focused on
bear biles effectiveness and its primary bile acid functions. concludingly, Bear bile and its bile acids play an important role in inhibition of
apoptosis and protection of Mitochondrial Function by regulating different proteins

Keywords

Ischemic stroke; Apoptosis; Bear bile

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References

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DOI: http://dx.doi.org/10.70711/pmr.v2i4.6105

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