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Research Progress on the Effect of NLRP3 Inflammasome on Myocardial Fibrosis and Drug Intervention

Jinqing Li, Yi Zang, Jia Li*

Abstract


Myocardial fibrosis is a common pathophysiological restructuring process that occurs in a variety of cardiovascular diseases. It is
characterized by the accumulation of extracellular matrix in the myocardium, which leads to arrhythmia and impaired cardiac function, and
eventually to heart failure. However, there is currently no specific clinical treatment to reverse or delay the progression of cardiac fibrosis. Nucleotide-binding oligomerized domand-like receptor protein 3 (NLRP3) inflammasome is a protein complex that is activated by endogenous
and exogenous signals and is involved in the development and progression of a variety of diseases. In recent years, studies have shown that
the abnormal activation of NLRP3 inflammasome is closely related to the occurrence and development of myocardial fibrosis. As a potential
target for the treatment of myocardial fibrosis, the NLRP3 inflammasome is expected to provide a new strategy and direction for the treatment
of myocardial fibrosis by inhibiting its overactivation. This paper aims to systematically review the impact of the NLRP3 inflammasome on
myocardial fibrosis and to explore advancements in its treatment strategies.

Keywords


Myocardial fibrosis; NLRP3 inflammasome; Drugs

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References


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DOI: http://dx.doi.org/10.70711/pmr.v2i4.6108

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