The Role of the Duodenum and Pancreas in Insulin Secretion Regulation in Type 2 Diabetes
Abstract
glucose metabolism. It analyzes their physiological functions, insulin secretion mechanisms, and pathological changes, while discussing recent research and therapeutic strategies for clinical practice.
Keywords
Full Text:
PDFReferences
[1] Kotwas A, Karakiewicz B, Zabielska P, Wieder-Huszla S, Jurczak A. Epidemiological factors for type 2 diabetes mellitus: evidence from
the Global Burden of Disease. Arch Public Health. 2021; 79(1): 110.
[2] Deng Y, Li N, Wu Y, et al. Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019.
Front Endocrinol (Lausanne). 2021; 12: 672350.
[3] Bello-Chavolla OY, Antonio-Villa NE, Vargas-Vzquez A, vila-Funes JA, Aguilar-Salinas CA. Pathophysiological Mechanisms Linking Type 2 Diabetes and Dementia: Review of Evidence from Clinical, Translational and Epidemiological Research. Curr Diabetes Rev.
2019; 15(6): 456-470.
[4] Iwase M, Fujii H, Idewaki Y, et al. Prospective study of cancer in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry.
Diabetol Int. 2019; 10(4): 260-267.
[5] Pyle L, Kelsey MM. Youth-onset type 2 diabetes: translating epidemiology into clinical trials. Diabetologia. 2021; 64(8): 1709-1716.
[6] Wu Y, Fu R, Lei C, et al. Estimates of Type 2 Diabetes Mellitus Burden Attributable to Particulate Matter Pollution and Its 30-Year
Change Patterns: A Systematic Analysis of Data From the Global Burden of Disease Study 2019. Front Endocrinol (Lausanne). 2021;
12: 689079.
[7] Del Toro C, Cabrera-Aguirre A, Casillas J, et al. Imaging spectrum of non-neoplastic and neoplastic conditions of the duodenum: a pictorial review. Abdom Radiol (NY). 2023; 48(7): 2237-2257.
[8] Hopson P, Smadi Y, Mehta V, Patel S, Mehta D, Horvath K. Assessment of exocrine pancreatic function in children and adolescents with
direct and indirect testing. Front Pediatr. 2022; 10: 908542.
[9] Lendoire M, Maki H, Haddad A, Jain AJ, Vauthey JN. Biliary Anatomy 2.0 Quiz: Test Your Knowledge. J Gastrointest Surg. 2023;
27(7): 1510-1529.
[10] Cao L, An Y, Liu H, et al. Global epidemiology of type 2 diabetes in patients with NAFLD or MAFLD: a systematic review and metaanalysis. BMC Med. 2024; 22(1): 101.
[11] Rancire F, Botton J, Slama R, et al. Exposure to Bisphenol A and Bisphenol S and Incident Type 2 Diabetes: A Case-Cohort Study in
the French Cohort D.E.S.I.R. Environ Health Perspect. 2019; 127(10): 107013.
[12] Omer E, Chiodi C. Fat digestion and absorption: Normal physiology and pathophysiology of malabsorption, including diagnostic testing. Nutr Clin Pract. 2024; 39 Suppl 1: S6-S16.
[13] Sukhbaatar N, Schller M, Fritsch SD, et al. Duodenal macrophages control dietary iron absorption via local degradation of transferrin.
Blood. 2023; 141(23): 2878-2890.
[14] Bailey CJ, Flatt PR. Duodenal enteroendocrine cells and GIP as treatment targets for obesity and type 2 diabetes. Peptides. 2024; 174:
171168.
[15] Lee S, Chung MJ, Ahn M, et al. Surfactant-like photosensitizer for endoscopic duodenal ablation: Modulating meal-stimulated incretin
hormones in obese and type 2 diabetes. Biomaterials. 2023; 302: 122336.
[16] Luziga C. Immunoreactivity of cytotoxic T-lymphocyte antigen 2 alpha in mouse pancreatic islet cells. Anat Histol Embryol. 2020;
49(3): 382-389.
[17] Rugivarodom M, Geeratragool T, Pausawasdi N, Charatcharoenwitthaya P. Fatty Pancreas: Linking Pancreas Pathophysiology to Nonalcoholic Fatty Liver Disease. J Clin Transl Hepatol. 2022; 10(6): 1229-1239.
[18] Imamura Y, Kumagi T, Kuroda T, et al. Pancreas stiffness in liver cirrhosis is an indicator of insulin secretion caused by portal hypertension and pancreatic congestion. Hepatol Res. 2021; 51(7): 775-785.
[19] Yalin A, ?arkici G, Kola UK. PKR inhibitors suppress endoplasmic reticulum stress and subdue glucolipotoxicity-mediated impairment of insulin secretion in pancreatic beta cells. Turk J Biol. 2020; 44(2): 93-102.
[20] Zhang Q, Xiao X, Zheng J, et al. DNA methylation regulates pancreatic gene expression and links maternal high-fat diet to the offspring
glucose metabolism. J Nutr Biochem. 2023; 123: 109490.
[21] Moss ND, Wells KL, Theis A, et al. Modulation of insulin secretion by RBFOX2-mediated alternative splicing. Nat Commun. 2023;
14(1): 7732.
[22] Duan S, Sawyer TW, Witten BL, Song H, Else T, Merchant JL. Spatial profiling reveals tissue-specific neuro-immune interactions in
gastroenteropancreatic neuroendocrine tumors. J Pathol. 2024; 262(3): 362-376.
[23] Venglovecz V, Hegyi P. GPR30 is a potential player between islet cells and ductal HCO3- secretion. Cell Calcium. 2024; 123: 102922.
[24] Banks EC. A Case of Medullary Exostosis. Northwest Med Surg J. 1849; 2(1): 26-28.
[25] Zhou Y, Komnick MR, Sepulveda F, et al. Inducible, but not constitutive, pancreatic REG/Reg isoforms are regulated by intestinal
microbiota and pancreatic diseases. bioRxiv. 2024.
[26] Shirai H, Ito C, Tsukada K. pH-taxis drives aerobic bacteria in duodenum to migrate into the pancreas with tumors. Sci Rep. 2022;
12(1): 1783.
[27] Walker EG, Lo KR, Pahl MC, et al. An extract of hops (Humulus lupulus L.) modulates gut peptide hormone secretion and reduces energy intake in healthy-weight men: a randomized, crossover clinical trial. Am J Clin Nutr. 2022; 115(3): 925-940.
[28] Shirai H, Tsukada K. Understanding bacterial infiltration of the pancreas through a deformable pancreatic duct. J Biomech. 2023; 162:
111883.
[29] Nie L, Yan Q, Zhang S, Cao Y, Zhou X. Duodenal Mucosa: A New Target for the Treatment of Type 2 Diabetes. Endocr Pract. 2023;
29(1): 53-59.
[30] Imai J. Identification of islet cell characteristics in humans with type 2 diabetes by single-cell sequencing. J Diabetes Investig. 2022;
13(10): 1646-1648.
[31] Sibthorpe PEM, Fitzgerald DM, Sillence MN, de Laat MA. Studies in vitro of equine intestinal glucagon-like peptide-2 secretion. J
Equine Vet Sci. 2024; 142: 105179.
[32] Son J, Accili D. Reversing pancreatic ?-cell dedifferentiation in the treatment of type 2 diabetes. Exp Mol Med. 2023; 55(8): 1652-1658.
[33] Cottet-Dumoulin D, Fonseca LM, Bignard J, et al. Identification of newly synthetized proteins by mass spectrometry to understand
palmitate-induced early cellular changes in pancreatic islets. Am J Physiol Endocrinol Metab. 2023; 325(1): E21-E31.
[34] Daniel P, Krishnan M, Prasad M, Babu S, Vijayalakshmi TM. Views on high-fat diet linked insulin resistance. Bioinformation. 2022;
18(1): 50-52.
[35] St Onge E. Diabetes: Pharmacotherapy for Type 2 Diabetes. FP Essent. 2021; 504: 22-27.
[36] Bahiru E, Hsiao R, Phillipson D, Watson KE. Mechanisms and Treatment of Dyslipidemia in Diabetes. Curr Cardiol Rep. 2021;
23(4): 26.
[37] Affinati AH, Esfandiari NH, Oral EA, Kraftson AT. Bariatric Surgery in the Treatment of Type 2 Diabetes. Curr Diab Rep. 2019;
19(12): 156.
[38] Mishra AS, Vasanthan M, Malliappan SP. Drug Repurposing: A Leading Strategy for New Threats and Targets. ACS Pharmacol Transl
Sci. 2024; 7(4): 915-932.
[39] van Baar ACG, Holleman F, Crenier L, et al. Endoscopic duodenal mucosal resurfacing for the treatment of type 2 diabetes mellitus: one
year results from the first international, open-label, prospective, multicentre study. Gut. 2020; 69(2): 295-303.
[40] Musso G, Pinach S, Saba F, De Michieli F, Cassader M, Gambino R. Endoscopic duodenal mucosa ablation techniques for diabetes and
nonalcoholic fatty liver disease: A systematic review. Med. 2024; 5(7): 735-758.e2.
[41] Finze A, Otto M, Khler G. Removable Transduodenal Bypass: Development of a New Endoscopic Concept. Visc Med. 2023;
39(3-4): 87-92.
[42] Kapeluto JE, Tchernof A, Masckauchan D, et al. Ten-year remission rates in insulin-treated type 2 diabetes after biliopancreatic diversion with duodenal switch. Surg Obes Relat Dis. 2020; 16(11): 1701-1712.
DOI: http://dx.doi.org/10.70711/pmr.v2i4.6109
Refbacks
- There are currently no refbacks.
