Construction and Validation of a Nomogram for Patients with Lentigo Maligna Melanoma: A SEER-based Study

Abstract

Aim: Based on data extracted from the Surveillance, Epidemiology, and End Results (SEER) database, we constructed and
predicted the 1-, 3-, and 5-year overall survival (OS) rates of patients with lentigo maligna melanoma (LMM). Method: Clinical data
from 7, 833 SEER database LMM patients (2010-2015) were split 7:3 into training and validation cohorts. Univariate and multivariate
Cox regression on the training cohort identified independent prognostic factors, used to develop and validate a nomogram predicting 1,
3, and 5-year OS. Nomogram performance was assessed using C-index, calibration curves, ROC curves, and Kaplan-Meier curves analyzed survival differences between high- and low-risk groups defined by the nomogram. Result: Age, sex, primary site of occurrence,
AJCC stage, T stage, M stage, and surgical intervention were identified as independent prognostic factors affecting the outcomes of lentigo maligna melanoma.