Diagnostic Value of miR-425-5p in Endometrial Carcinoma and its Effect on Proliferation, Migration and Apoptosis of Endometrial Carcinoma Cells
Abstract
This study highlights miR-425-5p as a potential diagnostic and therapeutic target in endometrial cancer (EC). Elevated miR-425-5p
levels in ECtissues and serum correlate with advanced FIGO stages, lymph node metastasis, and poor differentiation (AUC: 0.782 and 0.762
for tissue/serum, respectively). Inhibiting miR-425-5pin Ishikawa cells reduced proliferation, migration, and anti-apoptotic proteins (Bcl-2,
CyclinD1, PCNA, MMP9) while increasing apoptosis and pro-apoptotic Bax. These findings underscore miR-425-5prole in EC progression
and its promise for diagnosis and targeted therapy.
levels in ECtissues and serum correlate with advanced FIGO stages, lymph node metastasis, and poor differentiation (AUC: 0.782 and 0.762
for tissue/serum, respectively). Inhibiting miR-425-5pin Ishikawa cells reduced proliferation, migration, and anti-apoptotic proteins (Bcl-2,
CyclinD1, PCNA, MMP9) while increasing apoptosis and pro-apoptotic Bax. These findings underscore miR-425-5prole in EC progression
and its promise for diagnosis and targeted therapy.
Keywords
Endometrial carcinoma; Mir-425-5p; Cells migration
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DOI: http://dx.doi.org/10.70711/pmr.v2i6.7261
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