The Intervention Value of Ophiopogon Glycosides D in Preventing Ferroptosis in Cardiomyocytes was Evaluated Prospectively

Abstract

Myocardial ferroptosis, a critical pathological mechanism in cardiovascular disease progression, causes irreversible myocardial
damage through iron-dependent lipid peroxidation cascade reactions, making it a potential therapeutic target for severe conditions like heart
failure. As the core active component of the traditional Chinese medicine Ophiopogon japonicus, Ophiopogon glycoside D has shown significant antioxidant and cellular protective potential in preliminary studies. Guided by bioinformatics analyses that identified the SLC7A11/GPX4
axis as a key ferroptosis module and OPD as its potential modulator, However, its specific role in regulating myocardial ferroptosis remains
unclear. This study establishes a multi-level validation system to systematically elucidate its intervention mechanisms, while evaluating clinical application prospects from a translational medicine perspective. The findings provide theoretical support and experimental evidence for the
prospective application of Ophiopogon glycoside D in myocardial protection.