Clinical Characteristics and Antimicrobial Resistance Patterns of Pseudomonas Aeruginosa Infections in a Tertiary Hospital in Chongqing: A Retrospective Study from 2021 to 2024
Abstract
Methods: Retrospective analysis was performed on clinical data of a primary hospital in Chongqing from January 2021 to December 2024.
Results: Among the total number of 722 patients (of whom 501 were male and 221 were female with an average age of 63.6 ± 12.4), most
patients displayed increased inflammatory indicators. 124 males (17.2%) had CRP ? 100 mg/L; 251 individuals (34.8%) showed WBC ?
9.5 × 109 /L; 151 (20.9%) displayed PCT ? 0.5 ?g/L. In patients with pulmonary (n = 195) and otolaryngologic/head neck cancer (n = 150),
infections were seen, and increasing trend by year was seen. The other cases were from gastrointestinal (n=112), hepatobiliary (n=52), and
gynecological (n=48). The antimicrobial susceptibility was still high (?80%) to amikacin(?96.9%), cefe pime, cefepime(ciprofloxacin),
levofloxacin(>80%), meropenem (>80% ), imipenem (>80% ), piperacillin -tazobactam (>80% ), ceftazidime. Cefoperazone-sulbactam susceptibility: ?70% Aztreonam susceptibility: ?50% After the treatment, 108 patients ( 14.9 %) were better and discharged; 46 ( 6.4 %) died.
Conclusions: P. aeruginosa infection of cancer patient has a tendency to correlate with high levels of inflammatory markers and also co-infection is very common in case of immunocompromised patients. Carbapenem-resistant P. aeruginosa (CRPA) rate 8-15%. Strengthen the use of
antibiotics rationally and slow down the development of resistance.
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DOI: http://dx.doi.org/10.70711/pmr.v2i7.7716
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