Qixuan Song; Linxuan Zou; Zhuofan Dong; Junwei Zong*

doi:10.70711/pmr.v3i1.8067

The MicrobiotaPyroptosisWound Healing Axis: An Emerging Paradigm for Chronic Wound Regulation

Qixuan Song, Linxuan Zou, Zhuofan Dong, Junwei Zong*

Abstract

Chronic woundsincluding diabetic foot ulcers, venous leg ulcers, and pressure injuriesrepresent a persistent therapeutic
challenge driven by sustained infection, uncontrolled inflammation, and defective tissue regeneration. Recent evidence highlights the critical role of the wound microbiota in modulating host immune responses and cell death pathways. Among them, pyroptosisa caspase-mediated inflammatory form of programmed cell deathhas emerged as a central determinant of the wound microenvironment. This review
integrates microbiological and immunological insights into a unifying framework termed the "microbiotapyroptosiswound healing axis."
We summarize how microbial dysbiosis promotes inflammasome activation and pyroptotic cell death, leading to sustained inflammation
and delayed repair. We also discuss therapeutic interventionsincluding pharmacological inhibitors, natural compounds, antimicrobial
peptides, probiotics, and bioactive biomaterialsthat target this axis to restore immune homeostasis and accelerate healing. Understanding the bidirectional regulation between microbial ecology and pyroptotic signaling may provide new translational strategies for chronic
wound management.

Keywords

Pyroptosis; Microbiota; Inflammasome; Chronic wound; Diabetic ulcer; Immunomodulation; Biomaterials

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DOI: http://dx.doi.org/10.70711/pmr.v3i1.8067

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