The Relationship between MFN2 Expression, Immune Cell Infiltration and Prognosis in Breast Cancer
Abstract
correlation with tumor immune infiltration by TIMER database. Screen Mfn2 interacting protein molecules and pathways through GO,
KEGG and STRING analysis. Results: Mfn2 expression in breast cancer was low and varied among subtypes (P<0.001), related to immune cell infiltration abundance. There was a difference in DSS expression (P<0.05). Mfn2 was prone to modifications and interacted with
multiple proteins, mainly involved in ERK and AKT pathway regulation. Conclusion: Mfn2 expression in different subtypes has tissue
heterogeneity and is closely related to infiltrating immune cells. Its differential expression may reflect the clinical therapeutic benefit of
dendritic cell immunotherapy for different subtypes.
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DOI: http://dx.doi.org/10.70711/pmr.v2i8.8270
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