Application and Mechanism Study of Du Meridian 
Electroacupuncture in Spinal Cord Injury

Xianghua Li; Haijiao Bao; Hao Qi; Xin Liu; Yuting Lin*

doi:10.70711/pmr.v3i3.8638

Application and Mechanism Study of Du Meridian Electroacupuncture in Spinal Cord Injury

Xianghua Li, Haijiao Bao, Hao Qi, Xin Liu, Yuting Lin*

Abstract

Spinal cord injury is a neurological disease with high disability and mortality rates, and currently lacks specific treatments. Du Meridian electroacupuncture, as a combination of traditional Chinese medicine therapy and modern electrical stimulation technology, regulates
Qi and blood and improves circulation by stimulating acupoints on the Du Meridian, and promotes spinal cord repair through a multi-target
mechanism. It has clear effects in inhibiting cell apoptosis, regulating neuroinflammation, and activating neurotrophic pathways. In particular,
combined with rehabilitation training, hyperbaric oxygen therapy, and other comprehensive treatments, it can significantly improve patients'
motor and sensory functions and quality of life. However, this therapy still faces challenges such as insufficient clinical evidence, incomplete
understanding of the mechanism, and lack of parameter standardization. Future research should promote multi-center studies to achieve its
standardization and widespread application.

Keywords

Du Meridian Electroacupuncture; Spinal Cord Injury; Nerve Repair; Mechanism of Action; Comprehensive Treatment

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References

[1] Wenqiang L, Zhian C, Hua L, Wenqiang L, Zhian C, Hua L, et al. Neuromodulation techniques for the treatment of spinal cord injury:

current progress, challenges, and future prospects[J]. European Journal of Medical Research, 2025, 30(1): 495-495.

[2] Zeng Y S, Ding Y, Xu H Y, Zeng X, Lai B Q, Li G, Ma Y H. Electro-acupuncture and its combination with adult stem cell transplantation for spinal cord injury treatment: A summary of current laboratory findings and a review of literature[J]. CNS neuroscience & therapeutics, 2022, 28(5): 635-647.

[3] Jiang M C, Yan J D, Qing T, Li W, Xin Y L, Wei X L, Shu Y X. Effect of electroacupuncture on renal aging and renal phosphatidylinositide 3-kinase/protein kinase B signaling in aging mice[J]. Acupuncture research, 2025, 50(1): 84-89.

[4] Li J H, Wu W Z, Liu C Y, Wang X Q, Qin S, Zhao Y N, Li J H, Wu W Z, Liu C Y, Wang X Q, Qin S, Zhao Y N, et al. Effect of Tiaoshen

needling on plasma melatonin and cortisol in patients with chronic insomnia[J]. Acupuncture research, 2021, 46(8): 690-694.

[5] Xiao X R, Deng Q W, Zeng X, Lai B Q, Ma Y H, Li G, Xiao X R, Deng Q W, Zeng X, Lai B Q, Ma Y H, Li G, et al. Transcription Profiling of a Revealed the Potential Molecular Mechanism of Governor Vessel Electroacupuncture for Spinal Cord Injury in Rats[J]. Neurospine, 2022, 19(3): 757-769.

[6] Xu H Y, Yang Y, Deng Q W, Zhang B B, Ruan J W, Jin H, et al. Governor Vessel electro-acupuncture promotes the intrinsic growth ability of spinal neurons through activating CGRP/?CaMKII/NT-3 pathway after spinal cord injury[J]. Journal of neurotrauma,

[7] Zou Y Y, Zhang H Y, Ye J J, Lu B, Li H J. WU Xu's experience of sequential therapy for peripheral facial paralysis[J]. Chinese acupuncture & moxibustion, 2022, 42(4): 425-428.

[8] [14] Li J W, Hu Y C, Wang Y Y, Mei J J, Gao J, Ren B B, [14] Li J W, Hu Y C, Wang Y Y, Mei J J, Gao J, Ren B B, et al. Effect of electroacupuncture of Governor Vessel on expression of GAD67 and GABA-T in cerebral cortex of rats with post-stroke limb spasticity[J].

Acupuncture research, 2022, 47(8): 703-709.

[9] Tong T T, Wang Y, Li K W, Zhang L D, Wu X Q, Wang J L, Tong T T, Wang Y, Li K W, Zhang L D, Wu X Q, Wang J L, et al. Effect

of Tongdu Tiaoshen electroacupuncture pretreatment on PPAR?-mediated pyroptosis of cerebral cortex in rats with cerebral ischemia

reperfusion injury[J]. Chinese acupuncture & moxibustion, 2023, 43(7): 783-792.

[10] Wang Y Y, Li R Q, Li J W, Mei J J, Zhang L H, Zhang J Y, Guo J. Effects of Governor Vessel electroacupuncture on chloridion homeostasis in the cortex of rats with limb spasm after cerebral ischemia-reperfusion[J]. Acupuncture research, 2023, 48(9): 860-869.

[11] Li T, Wu M, Tian J, Li Y, Li Z. Effect of Electroacupuncture Stimulation on Brown Adipose Tissue Thermogenesis[J]. Journal of acupuncture and meridian studies, 2024, 17(1): 11-11.

[12] Wu M L, Duan Z Y, Chang W T, Gao J, Su K Q, Feng X D. Effect of electroacupuncture of Governor Vessel on mitochondrial fusion

and proliferation and differentiation of neural stem cells in spinal cord injury rats[J]. Acupuncture research, 2024, 49(2): 119-126.

[13] Cheng Y D, Yu Y L, Wang Y Q, Fan A, Yang H, Wang H L, Tang L G. Effects of lumbar-pelvic training combined with electroacupuncture on chronic nonspecific low back pain[J]. Medicine, 2023, 102(29): e34407-e34407.

DOI: http://dx.doi.org/10.70711/pmr.v3i3.8638

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