Study on the Efficacy and Safety of Propofol Combined with Oxetane for Anesthesia during ERCP in Elderly Patients

Abstract

Objective: To evaluate the efficacy and safety of propofol combined with oritavindol for anesthesia during ERCP in elderly
patients. Methods: From May 2023 to November 2024, 50 patients aged ?80 years undergoing elective ERCP were enrolled and randomly divided into the propofol-oritavindol group (C-O group, n=25) and the propofol-sufentanil group (C-S group, n=25). In the C-O
group, induction was performed with propofol 0.3 mg/kg + oritavindol 0.02 mg/kg, and maintenance was with propofol 0.6~0.8 mgkg
-h -; in the C-S group, induction was performed with propofol 0.35 mg/kg + sufentanil 0.1 ?g/kg, and maintenance was with propofol
0.6~0.7 mgkg-h-. Four major indicators, including hemodynamics, depth of anesthesia, quality of recovery, and adverse events, were
compared. Results: In the C-O group, intraoperative systolic blood pressure fluctuation, incidence of hypotension, and duration of BIS
<40 were all lower than those in the C-S group (P<0.05). The time to recovery of orientation and the time for Steward score to reach ?4
were both shorter in the C-O group than in the C-S group (P<0.05). The incidence of hypoxia, bradycardia, injection pain, and postoperative nausea and vomiting was also lower in the C-O group than in the C-S group (P<0.05). However, there were no significant differences
in operation time, anesthesia time, and sedation success rate between the two groups (P>0.05). Conclusion: Propofol combined with
oritavindol can provide stable hemodynamics, faster recovery, and fewer adverse events for elderly patients undergoing ERCP, making it
effective and safe.