Mechanisms and Clinical Significance of Metabolic 
Reprogramming in Pancreatic Cancer

Bin Zuo; Qiao Huang; Wei Yu; Chen Cheng; Xiuping Luo; Yang Liu

doi:10.70711/pmr.v3i4.8804

Mechanisms and Clinical Significance of Metabolic Reprogramming in Pancreatic Cancer

Bin Zuo, Qiao Huang, Wei Yu, Chen Cheng, Xiuping Luo, Yang Liu

Abstract

Pancreatic cancer is highly invasive with a poor prognosis, posing a critical challenge in oncology research. Metabolic reprogramming, a prominent feature of pancreatic cancer, is mainly characterized by abnormal activation of glycolysis, high dependence on glutamine
metabolism, and sustained hyperactivity of lipid synthesis. These metabolic changes not only provide energy and biosynthetic precursors for
the rapid proliferation of cancer cells but also maintain their survival and adaptability in the hypoxic and nutrient-depleted tumor microenvironment. Furthermore, metabolic reprogramming shapes an immunosuppressive microenvironment and promotes immune escape by releasing
lactic acid and consuming key nutrients. This review elaborates on the core molecular mechanisms of metabolic reprogramming in pancreatic
cancer, its interaction with the tumor microenvironment, and its significance in clinical diagnosis and treatment. It focuses on metabolic targeted therapy strategies, the application value of potential biomarkers, and the current challenges, aiming to provide new metabolic perspectives and strategic directions for the early diagnosis and treatment of pancreatic cancer.

Keywords

Pancreatic cancer; Metabolic reprogramming; Targeted therapy

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References

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DOI: http://dx.doi.org/10.70711/pmr.v3i4.8804

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