Research Progress on the Role of the Amygdala mTOR/ ERK Signaling Pathway in Synaptic Plasticity Changes in Post-Traumatic Stress Disorder
Abstract
aims to review the research progress of synaptic plasticity changes mediated by the mTOR/ERK signaling pathway in PTSD, elaborate on the
composition, function of the mTOR/ERK signaling pathway, and its mechanism of influencing synaptic plasticity in PTSD, analyze the current research status and limitations, and provide theoretical basis for in-depth understanding of the pathogenesis of PTSD and the development
of new therapeutic targets.
Keywords
Full Text:
PDFReferences
[1] Li Xue. Research on the Intervention Effect and Mechanism of Deep Brain Stimulation in the Treatment of Morphine Addiction [D].
Guangzhou Medical University, 2021.
[2] Xu Yifei. Study on the Efficacy and Mechanism of Anti-fatigue Nutrient Agents in Regulating Emotional Cognition and Long-Distance
Navigation Fatigue in Rats with Liver Depression and Spleen Deficiency Syndrome [D]. Beijing University of Chinese Medicine, 2022.
[3] Song Dake. Research on Candidate Drugs for Post-Traumatic Stress Disorder and Their Possible Mechanisms [D]. Military Academy of
Sciences, 2019.
[4] Wang Jun. Research on the Role of S1PR3 Specific Agonist RY-15 in Promoting Bacterial Clearance by Macrophages through the ERK
Pathway [D]. Zhejiang University, 2019. DOI: 10.27461/d.cnki.gzjdx.2019.001276.
[5] Huo Qing. Experimental Study on the Regulation of Fear Memory Generalization by eCBs in the Prefrontal Cortex [D]. Shaanxi Normal University, 2017.
[6] Yan Fengxia. The Mechanism of Dopamine D1 Receptor on the Behavioral Manifestations of PTSD Model Rats [D]. Liaoning: China
Medical University, 2017.
[7] Chen Guokun. Research on the Mechanism of the Rhythmic Gene Bmal1 Mediating Temporomandibular Joint Arthritis through Regulating the MAPK/ERK Signaling Pathway [D]. Shandong University, 2020. DOI: 10.27272/d.cnki.gshdu.2020.005989.
[8] Long Xiaobing. Research on the Regulatory Effect and Mechanism of miR-873a-5p Carried by Astrocyte Exosomes on the Phenotype
and Function of Microglia in Traumatic Brain Injury [D]. Huazhong University of Science and Technology, 2020. DOI: 10.27157/d.cnki.
ghzku.2020.000850.
[9] Ji Manman. Research on the Mechanism of Xianmaosan Glycoside Intervening PTSD-like Behaviors Based on the cAMP-PKA Signaling Pathway [D]. Anhui University of Chinese Medicine, 2023.
[10] Li Mi. Research on the Regulatory Mechanism of Electroacupuncture in Eliminating Fear Memory and Treating PTSD Rats Based on
Synaptic Plasticity and BDNF-TrkB Signaling Pathway [D]. Sichuan: Chengdu University of Traditional Chinese Medicine, 2019.
[11] Fu Jing. Research on the Mechanism of Rh-MANF Regulating Neuroinflammation in Traumatic Stress Disorder Rats by Regulating the
CEBPB/MALAT1/ERK Signaling Pathway [D]. Jinzhou Medical University, 2024. DOI: 10.27812/d.cnki.glnyx.2024.001071.
[12] Xiang Mingjun. Molecular Mechanism of 5-HT2AR/5-HT1AR in the Anxious-like Behavior of Traumatic Stress Disorder Mice [D].
Zhejiang University, 2018.
[13] Li Zhihua. The Mechanism of Extracellular Signal-Regulated Kinase (ERK) in the Regulation of Oral Facial Pain in the Insular Cortex
[D]. Zhengzhou University, 2018.
[14] Sun Lichong, Jing Yongshuai, Zhang Danxin. Progress in the Neuroprotective Effects of Tetrahydrocurcumin [J]. Chinese Journal of
Pharmacology and Toxicology, 2021, 35(10): 796-797.
[15] Liu Huan, Li Xiaoxue, Liao Yangyou, et al. The Regulation of GATA6 on Endothelial Cell Function and Its Molecular Mechanism [C]//
Abstracts of the Ninth Pan-Bohai Region Biochemistry and Molecular Biology Society Conference. Harbin City, Heilongjiang Province,
China, 2019: 28-28. DOI: 10.26914/c.cnkihy.2019.108090.dicine, 2019.
DOI: http://dx.doi.org/10.70711/pmr.v3i4.8805
Refbacks
- There are currently no refbacks.
