Research Progress on the Synergistic Mechanism of 
GABAergic Neurons in the Preoptic Area of the Hypothalamus
and Cholinergic System in the Basal Forebrain in Regulating
the Switching of Sleep-Wakefulness

Delin Ren

doi:10.70711/pmr.v3i5.8987

Research Progress on the Synergistic Mechanism of GABAergic Neurons in the Preoptic Area of the Hypothalamus and Cholinergic System in the Basal Forebrain in Regulating the Switching of Sleep-Wakefulness

Delin Ren

Abstract

Sleep-wake transition is an important physiological process in organisms, and its mechanism has always been a research hotspot in
the field of neuroscience. This article focuses on the collaborative mechanism between GABAergic neurons in the hypothalamic preoptic area
and the cholinergic system in the basal forebrain during sleep-wake transition. Firstly, it elaborates on the role of GABAergic neurons in the
hypothalamic preoptic area in promoting sleep and inhibiting neural activities related to awakening, as well as the crucial position of the basal forebrain cholinergic system in maintaining awakening. Then, it deeply analyzes the neural connections and signal transmission methods
between the two systems, and discusses how they achieve a smooth transition between sleep and awakening through a collaborative effect.
Studying the collaborative mechanism of these two systems is of great significance for in-depth understanding of the pathogenesis of sleep
disorders and the development of targeted treatment strategies.

Keywords

Hypothalamic preoptic area; GABAergic neurons; Basal forebrain cholinergic system; Sleep-wake transition; Collaborative mechanism

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References

[1] Zhao Shiyi. The Role of Basal Forebrain ?-Aminobutyric Acidergic Neurons in the Regulation of Anesthesia-Awakening [D].: Air Force

Military Medical University of the People's Liberation Army of China, 2020. DOI: 10.27002/d.cnki.gsjyu.2020.000245.

[2] Huo Jia. The Regulatory Role and Mechanism of the LHOrexin-NAc Neural Circuit in Anesthesia-Awakening [D].: Air Force Military

Medical University of the People's Liberation Army of China, 2025. DOI: 10.27002/d.cnki.gsjyu.2025.000072.

[3] Song Ge. Research on the Role of the Basal Forebrain GABAergic System in Sevoflurane Anesthesia [D].: Fourth Military Medical

University.

[4] Bao Chang. The Mechanism of Regulation of Gamma-Aminobutyric Acid Neurons in the Lateral Hypothalamic Region on Sevoflurane General Anesthesia-induced Awakening [D].: Shaanxi University of Traditional Chinese Medicine, 2023. DOI: 10.27294/d.cnki.

gsxzc.2023.000011.

[5] Su Weikun. Research on the Regulation of the Basal Forebrain ?-Aminobutyric Acidergic Neurons on Isoflurane Anesthesia Recovery in

Mice [D].: Fujian Medical University, 2023. DOI: 10.27020/d.cnki.gfjyu.2023.000793.

[6] Cheng Xuefeng. Research on the Role of Adenosine-Mediated Astrocytes in the Basal Forebrain Region in Sleep Regulation [D].

Guangdong: Guangzhou University of Traditional Chinese Medicine, 2022.

[7] Feng Zhenxin, Zhang Wei. Important Nuclei of General Anesthesia - The Blue Spot Nucleus [J]. Journal of Clinical Anesthesia, 2018,

34(12): 1231-1233.

[8] Qiu Gaolin. Research on the Mechanism of GABA Neurons in the Preoptic Area of the Hypothalamus in Dexmedetomidine Sedation

and Natural Sleep [D]. Anhui: Anhui Medical University, 2024.

[9] Tang Yu. Research on the Modulation of Arginine Vasopressin on GABAergic Synaptic Transmission of Neurons in the Hypothalamic

Preoptic Area [D]. Hubei: Huazhong University of Science and Technology, 2018.

[10] Qiu Gaolin. Research on the Mechanism of GABA Neurons in the Preoptic Area of the Hypothalamus in Dexmedetomidine Sedation

and Natural Sleep [D].: Anhui Medical University, 2024. DOI: 10.26921/d.cnki.ganyu.2024.000039.

[11] Sun Yanrong, Yang Qiyue, Qin Lihua, et al. Research on the Triggering of Perimenopausal Hot Flashes by TRPM2 Thermosensitive

Neurons in the Lateral Hypothalamic Region [J]. Journal of Anatomy, 2021, 44(S1): 83-83.

[12] Long, Wang Dan, Zhao Guangchao, et al. Whole-brain Neural Circuit Tracing of Dopamine Neurons in the Ventral Pallidal Region [J].

Modern Biomedical Progress, 2023, 23(11): 2008-2013. DOI: 10.13241/j.cnki.pmb.2023.11.002.

[13] Sun Yanrong, Yang Qiyue, Qin Lihua, et al. Research on the Triggering of Perimenopausal Hot Flashes by TRPM2 Thermosensitive

Neurons in the Lateral Hypothalamic Region [C]//The 2021 Annual Conference of the Chinese Society of Anatomy. Beijing, China,

2021: 108-108. DOI: 10.26914/c.cnkihy.2021.077951.

[14] Yang Yanfei, Huang Zhili. New Progress in the Study of Sleep-Wake Mechanism by Specific Control of Neuron Activity [J]. Journal of

Neuropharmacology, 2018, 8(1): 23-34. DOI: 10.3969/j.issn.2095-1396.2018.01.004.

[15] Li Jie. Neural Circuit Mechanisms of Basal Forebrain in Regulating Social Interaction Behaviors [D].: Zhejiang University, 2021. DOI:

10.27461/d.cnki.gzjdx.2021.003311.

DOI: http://dx.doi.org/10.70711/pmr.v3i5.8987

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