Research on Key Targets and Signaling Pathways of Sinomenine in the Treatment of Periodontitis: Network Pharmacology and Molecular Docking
Abstract
in adults. Sinomenine, an isoquinoline alkaloid from Sinomenium acutum, has anti-inflammatory and immunomodulatory activities, but its
role in periodontitis is not fully understood. Here, network pharmacology combined with molecular docking was used to explore sinomenines
potential mechanisms against periodontitis.A total of 158 intersecting targets were identified, and PPI analysis highlighted 10 hub genes (TNF,
IL6,AKT1, VEGFA, TP53, JUN, CASP3, PTGS2, MMP9, STAT3). GO and KEGG enrichment suggested involvement in inflammation, ap
optosis, and osteoclast differentiation, mainly through NF-?B, MAPK, JAK-STAT, and RANKRANKL pathways. Docking supported stable
binding between sinomenine and hub proteins (binding energies -6.8 to -9.2 kcal/mol), indicating a multi-target, multi-pathway therapeutic
potential for periodontitis.
Keywords
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[1] Aravindraja C, Jeepipalli S, Duncan W, Vekariya KM, Bahadekar S, Chan EKL, Kesavalu L. Unique miRomics Expression Profiles in
Tannerella forsythia-Infected Mandibles during Periodontitis Using Machine Learning [J]. International Journal of Molecular Sciences,
2023, 24(22): 16393.
[2] Kwon D, et al. Treponema denticola as a prognostic biomarker for periodontitis in dogs [J]. PLoS ONE, 2022, 17(1): e0262859 .
[3] Zhou LJ, et al. Periodontitis exacerbates atherosclerosis through Fusobacterium nucleatum-promoted hepatic glycolysis and lipogenesis
[J]. Cardiovascular Research, 2023, 119(8): 17061717.
[4] Fine DH, Patil AG, Velusamy SK.Aggregatibacter actinomycetemcomitans (Aa) Under the Radar: Myths and Misunderstandings of Aa
and Its Role in Aggressive Periodontitis [J]. Frontiers in Immunology, 2019, 10: 728.
[5] Teles F, et al.Viruses,periodontitis, and comorbidities [J]. Periodontology 2000, 2022, 89(1): 190206.
[6] Simpson TC, et al. Treatment of periodontitis for glycaemic control in people with diabetes mellitus [J]. Cochrane Database of System
atic Reviews, 2022, 4(4): CD004714 .
[7] Naderi S, Merchant AT. The Association Between Periodontitis and Cardiovascular Disease: an Update [J]. Current Atherosclerosis Re
ports, 2020, 22(10): 52.
DOI: http://dx.doi.org/10.70711/pmr.v3i6.9139
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