Advances in Microbial Research Related to Gastric Cardia Carcinoma
Abstract
China. Its pathogenesis involves genetics, environment, inflammation, and microorganisms. Previous studies mainly focused on Helicobacter
pylori(Hp) and non-GCA, while microbiome research on GCA has become a hotspot recently. With high-throughput sequencing, the roles of
dysbiotic oral, gastric, gut microbiota, fungi and viruses in GCA have been revealed. Microorganisms promote carcinogenesis via inducing
inflammation, generating carcinogenic metabolites, regulating host signaling, remodeling tumor microenvironment. This review summarizes
GCA-associated microbial features and key pathogens, discusses current limitations and future perspectives, providing a theoretical basis for
early screening, risk stratification and precise management of GCA.
Keywords
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DOI: http://dx.doi.org/10.70711/pmr.v3i7.9412
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