Research on the Molecular Mechanism and Targeted Intervention of Ferroptosis in Ischemia-Reperfusion Injury
Abstract
as an iron-dependent regulatory form of programmed cell death, has garnered considerable attention due to its critical role in IRI. This article
systematically elucidates the molecular regulatory mechanisms of osteoporosis in IRI, focusing on the "death triangle" composed of iron metabolism imbalance, lipid oxidation surge, and antioxidant defense system collapse. Further exploration is conducted on intervention strategies
centered around novel signaling axes such as lysosomal iron regulation, GPX4-dependent and non-dependent pathways, and TRIM28-IRP2.
Integrating the latest research advancements from 2025 to 2026, this study proposes a future direction toward transitioning from single-target
inhibition to multi modal combined interventions, providing novel theoretical perspectives and therapeutic targets for overcoming the clinical
challenge of IRI.
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DOI: http://dx.doi.org/10.70711/pmr.v3i7.9416
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