Research Progress on Alzheimer's Disease-Related Epigenetics

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder. The pathogenesis involves multiple factors including genetics and environment, as well as lifestyle, which can all contribute to the disease development through complex interactions between these
different elements in the human body, and this multifactorial nature makes the disease mechanism very complicated to study in clinical and
experimental settings. Epigenetic modifications can serve as a molecular bridge. It is worth noting that they connect environmental factors
and gene expression, and they are expected to play important role in onset and progression of AD because they provide a mechanism through
which external stimuli can influence internal genetic programs and cellular functions. In this review, we examine the mechanisms of DNA
methylation and histone modification. Also, non-coding RNA regulation is discussed in pathogenesis context so that we can understand how
these epigenetic changes affect the disease process and we can identify possible intervention points for therapeutic development in AD treatment. Then, early epigenetic-based biomarkers and potential therapeutic strategies are analyzed.