Extracellular Vesicles as Therapeutic Targets in Cerebrovascular Diseases
Abstract
disease progression and tissue repair by transporting bioactive molecules between cells. Pathogenic EVs can promote inflammation, thrombosis, and blood–brain barrier damage, while therapeutic EVs, particularly stem-cell-derived and engineered EVs, may support neurovascular
repair, angiogenesis, and targeted drug delivery. Despite their promise, clinical application is limited by challenges related to standardization,
safety, targeting, and large-scale production. EVs represent both potential therapeutic targets and innovative treatment vehicles for cerebrovascular diseases.
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[1] Bang O Y, Kim E H, Cha J M. Extracellular vesicles: New players in cerebrovascular diseases[J]. Journal of Stroke, 2022, 24(2): 175-
190.
[2] Doeppner T R, Herz J, Görgens A, et al. Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic
immunosuppression[J]. Stem Cells Translational Medicine, 2015, 4(10): 1131-1143.
[3] Ghosh R, Stamova B, Jickling G C. Extracellular vesicles as tools and targets in therapy for diseases[J]. Signal Transduction and Targeted Therapy, 2024, 9: 27.
[4] Lai C P K, Breakefield X O. Role of exosomes/microvesicles in the nervous system and use in emerging therapies[J]. Frontiers in Physiology, 2012, 3: 228.
[5] Liu W, Li R, Yin J, et al. Extracellular vesicles as a potential therapy for stroke[J]. International Journal of Molecular Sciences, 2025,
26(7): 3130.
[6] Lötvall J, Hill A F, Hochberg F, et al. Minimal experimental requirements for definition of extracellular vesicles and their functions[J].
Journal of Extracellular Vesicles, 2014, 3(1): 26913.
[7] Otero-Ortega L, Laso-García F, Gómez-de Frutos M C, et al. White matter repair after extracellular vesicles administration in an experimental animal model of subcortical stroke[J]. Scientific Reports, 2017, 7: 44433.
[8] Théry C, Witwer K W, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018[J]. Journal of Extracellular Vesicles, 2018, 7(1): 1535750.
[9] Tian T, Cao L, He C, et al. Targeted delivery of extracellular vesicles: Mechanisms, strategies and clinical translation[J]. Journal of Nanobiotechnology, 2023, 21: 432.
[10] Xin H, Li Y, Liu Z, et al. MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles[J]. Stem Cells, 2013, 31(12): 2737-2746.
[11] Yang J, Zhang X, Chen X, et al. Exosome mediated delivery of miR-124 promotes neurogenesis after ischemia[J]. Molecular Therapy—
Nucleic Acids, 2017, 7: 278-287.
[12] Zhang Z G, Buller B, Chopp M. Exosomes—Beyond stem cells for restorative therapy in stroke and neurological injury[J]. Nature Reviews Neurology, 2019, 15(4): 193-203.
DOI: http://dx.doi.org/10.70711/pmr.v3i9.9892
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