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Extracellular Vesicles as Therapeutic Targets in Cerebrovascular Diseases

Yu Gu

Abstract


Cerebrovascular diseases are major causes of death and disability worldwide. Extracellular vesicles (EVs) play important roles in
disease progression and tissue repair by transporting bioactive molecules between cells. Pathogenic EVs can promote inflammation, thrombosis, and blood–brain barrier damage, while therapeutic EVs, particularly stem-cell-derived and engineered EVs, may support neurovascular
repair, angiogenesis, and targeted drug delivery. Despite their promise, clinical application is limited by challenges related to standardization,
safety, targeting, and large-scale production. EVs represent both potential therapeutic targets and innovative treatment vehicles for cerebrovascular diseases.

Keywords


Extracellular vesicles; Exosomes; Cerebrovascular diseases; Ischemic stroke; Hemorrhagic stroke; Blood–brain barrier

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References


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DOI: http://dx.doi.org/10.70711/pmr.v3i9.9892

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