Review on the Impact of Deubiquitinating Enzyme 
USP50 on the Degradation and Function of TMEM173

Mengjie Li; Yinuo Sun; Hongyan Gao

doi:10.70711/mhr.v2i3.4893

Review on the Impact of Deubiquitinating Enzyme USP50 on the Degradation and Function of TMEM173

Mengjie Li, Yinuo Sun, Hongyan Gao

Abstract

Deubiquitinating enzyme USP50 is involved in the regulation of various biological processes, including the cell cycle, innate immune response, DNA repair, and the regulation of the NF-?B signaling pathway. TMEM173 plays a critical role in antiviral and antitumor
immune responses, making the regulation of TMEM173 by USP50 a focal point in the development of antiviral and antitumor drugs. An indepth investigation into how USP50 affects the degradation and function of TMEM173 is expected to provide strong support for drug development targeting this important pathway and may open up new approaches for antiviral and antitumor therapies. Moreover, the regulatory
effect of USP50 on TMEM173 may also be closely related to the pathogenesis of autoimmune diseases. Exploring the role of USP50 in these
diseases may offer new insights into treatment strategies for autoimmune conditions.

Keywords

Deubiquitinating enzyme USP50; TMEM173; Degradation; Function

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DOI: http://dx.doi.org/10.70711/mhr.v2i3.4893

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