A Yeast-derived Glutathione: Clinical Trials and Efficacy Evaluation in Whitening, Anti-oxidation, Alcohol Detoxification,Liver Protection, and Sports Fatigue Relief

Abstract

Yeast-derived glutathione (GSH) has gained significant attention for its multifaceted role in enhancing human health. This review explores the clinical efficacy of GSH in areas such as skin whitening, antioxidation, alcohol detoxification, liver protection, and sports fatigue relief. GSH, a potent antioxidant synthesized in the liver, plays a crucial role in detoxification processes, immune function, and oxidative stress reduction. Recent studies have demonstrated that yeast-derived GSH is bioavailable and effective when administered both orally and topically. In skin health, clinical trials have shown significant improvements in pigmentation and skin brightness, with reductions in UV-induced spots. GSH also supports liver health by aiding detoxification processes and protecting against alcohol-induced damage, as evidenced by decreased liver enzyme levels in patients with nonalcoholic fatty liver disease (NAFLD). Additionally, supplementation with GSH has been found to reduce fatigue and improve recovery in athletes, suggesting its potential in sports performance enhancement. These findings underscore the broad therapeutic potential of yeast-derived GSH across various health domains, warranting further research to optimize its application and efficacy in clinical settings.