Rhubarb Extract Improves Idiopathic Pulmonary Fibrosis 
in Mice by Inhibiting the p38 MAPK/NF-?B Pathway

Mingtong Xu; Li Han*; Xi Lu; Jingru Chen; Tonghui Yuan

doi:10.70711/mhr.v2i5.6279

Rhubarb Extract Improves Idiopathic Pulmonary Fibrosis in Mice by Inhibiting the p38 MAPK/NF-?B Pathway

Mingtong Xu, Li Han*, Xi Lu, Jingru Chen, Tonghui Yuan

Abstract

IPF lacks effective treatment. Rhein in rhubarb has anti - infl ammatory and anti - fi brotic potential. This mouse - model study assesses its impact on the p38 MAPK/NF - ?B pathway, aiming to explore protective effects and optimal dosage for IPF treatment.

Keywords

Pulmonary fibrosis; Rhein; p38 MAPK/NF - ?B signaling pathway; Therapeutic mechanism

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DOI: http://dx.doi.org/10.70711/mhr.v2i5.6279

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