How the Brain Regulates Food Intake?
Abstract
in regulating food intake. Studies have shown that the hypothalamus maintains energy homeostasis by integrating hormonal signals such as
leptin, mTOR, and AMPK. Damage to the hypothalamus may lead to eating-related disorders such as obesity or anorexia. Research suggests
that leptin reduces food intake by suppressing appetite, while mTOR controls food intake by increasing signaling through central leucine management. Stress has also been linked to hypothalamic lesions. Long-term stress can disrupt leptin function, leading to uncontrolled appetite.
This article suggests that hypothalamic damage may precede the onset of diseases such as obesity and exacerbate metabolic disorders by altering dietary patterns. The combined use of leptin and insulin to regulate hypothalamic hormones may be an effective strategy for intervention
in obesity, but further research is needed on its mechanism of use. Future research should focus on multi-hormone combination therapy to
develop more precise clinical intervention methods.
Keywords
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[1] Baskin, D., Blevins, J., & Schwartz, M. (2001). How the brain regulates food intake and body weight: the role of leptin. Journal Of
Pediatric Endocrinology & Metabolism: JPEM. Retrieved from https://europepmc.org/article/med/11837495.
[2] Buijs, R., & Van Eden, C. (2000). The integration of stress by the hypothalamus, amygdala and prefrontal cortex: balance between the
autonomic nervous system and the neuroendocrine system. Progress In Brain Research, 117-132. https://doi.org/10.1016/s0079-6123-
(00)26011-1
[3] Choi, S., & Dallman, M. (1999). Hypothalamic Obesity: Multiple Routes Mediated by Loss of Function in Medial Cell Groups1. Endocrinology, 140(9), 4081-4088. https://doi.org/10.1210/endo.140.9.6964
[4] Cota, D., Proulx, K., Smith, K., Kozma, S., Thomas, G., Woods, S., & Seeley, R. (2006). Hypothalamic mTOR Signaling Regulates
Food Intake. Science, 312(5775), 927-930. https://doi.org/10.1126/science.1124147
[5] Lu, S. (2016). Obesity and the growing brain. https://www.apa.org. Retrieved 29 April 2022, from https://www.apa.org/monitor/2016/06/
obesity-brain.
[6] Lpez, M., Lelliott, C., & Vidal-Puig, A. (2007). Hypothalamic fatty acid metabolism: A housekeeping pathway that regulates food intake. Bioessays, 29(3), 248-261. https://doi.org/10.1002/bies.20539
[7] McMinn, J., Baskin, D., & Schwartz, M. (2000). Neuroendocrine mechanisms regulating food intake and body weight. Obesity Reviews,
1(1), 37-46. https://doi.org/10.1046/j.1467-789x.2000.00007.x
[8] Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y., Lee, A., & Xue, B. et al. (2004). AMP-kinase regulates food intake by responding to
hormonal and nutrient signals in the hypothalamus. Nature, 428(6982), 569-574. https://doi.org/10.1038/nature02440
[9] Morrison, C. (2009). Leptin signaling in brain: A link between nutrition and cognition?. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease, 1792(5), 401-408. https://doi.org/10.1016/j.bbadis.2008.12.004
[10] Obesity and the Brain. Brainfacts.org. (2009). Retrieved 29 April 2022, from https://www.brainfacts.org/archives/2009/obesity-and-thebrain.
[11] Roger, C., Lasbleiz, A., Guye, M., Dutour, A., Gaborit, B., & Ranjeva, J. (2022). The Role of the Human Hypothalamus in Food Intake
Networks: An MRI Perspective. Frontiers In Nutrition, 8. https://doi.org/10.3389/fnut.2021.760914
[12] Roth, C. (2015). Hypothalamic Obesity in Craniopharyngioma Patients: Disturbed Energy Homeostasis Related to Extent of Hypothalamic Damage and Its Implication for Obesity Intervention. Journal Of Clinical Medicine, 4(9), 1774- 1797. https://doi.org/10.3390/
jcm4091774
[13] Rouach, V., Bloch, M., Rosenberg, N., Gilad, S., Limor, R., Stern, N., & Greenman, Y. (2007). The acute ghrelin response to a psychological stress challenge does not predict the post-stress urge to eat. Psychoneuroendocrinology, 32(6), 693- 702. https://doi.org/10.1016/
j.psyneuen.2007.04.010
[14] Seoane, L., Barja-Fenndez, S., Leis, R., & Casanueva, F. (2014). Drug development strategies for the treatment of obesity: how to ensure efficacy, safety, and sustainable weight loss. Drug Design, Development And Therapy, 2391. https://doi.org/10.2147/dddt.
s53129
[15] Sominsky, L., & Spencer, S. (2014). Eating behavior and stress: a pathway to obesity. Frontiers In Psychology, 5. https://doi.
org/10.3389/fpsyg.2014.00434
[16] Tolle, V., Ramoz, N., & Epelbaum, J. (2021). Is there a hypothalamic basis for anorexia nervosa?. The Human Hypothalamus - Neuroendocrine Disorders, 405- 424. https://doi.org/10.1016/b978-0-12-820683-6.00030-0
[17] Why stress causes people to overeat - Harvard Health. Harvard Health. (2021). Retrieved from https://www.health.harvard.edu/stayinghealthy/why-stresscauses-people-to-overeat.
[18] Woods, S., Lutz, T., Geary, N., & Langhans, W. (2006). Pancreatic signals controlling food intake; insulin, glucagon and amylin. Philosophical Transactions Of The Royal Society B: Biological Sciences, 361(1471), 1219-1235. https://doi.org/10.1098/rstb.2006.1858
[19] Woods, S., Seeley, R., Porte, D., & Schwartz, M. (1998). Signals That Regulate Food Intake and Energy Homeostasis. Science,
280(5368), 1378-1383. https://doi.org/10.1126/science.280.5368.1378
[20] Yang, R., & Barouch, L. (2007). Leptin Signaling and Obesity. Circulation Research, 101(6), 545-559. https://doi.org/10.1161/
circresaha.107.156596
DOI: http://dx.doi.org/10.70711/mhr.v2i6.6840
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