Research Progress on the Structural Modification and Antitumor Activity of Sinomenine Derivatives
Abstract
with a broad spectrum of pharmacological activities and great potential as a lead compound. Historically, research on its derivatives has primarily focused on anti-inflammatory and immunomodulatory activities. However, in recent years, its potential value in the field of antitumor
therapy has garnered increasing attention. This paper focuses on the chemical modification strategies of the core structure (A/B/C rings) of
sinomenine, and systematically reviews the progress in structural optimization of sinomenine derivatives over the past five years. Special emphasis is placed on their antitumor pharmacological activities and related mechanisms of action. The aim is to provide a theoretical basis and
design ideas for the development of novel antitumor drugs based on the sinomenine scaffold.
Keywords
Full Text:
PDFReferences
[1] Torre, L. A., Siegel, R. L., Ward, E. M., & Jemal, A. (2016). Global Cancer Incidence and Mortality Rates and Trends--An Update. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 25(1), 16-27.
[2] OUNR, MOUSSAYE, WHEATENJ. Theside effects of platinum-based chemotherapy drugs: a review for chemists[J]. Dalton Trans,
2018, 47( 19): 6645-6653.
[3] Fang Miao, Wang Degang, Liu Peiqing. Study on the Antitumor Mechanisms of Natural Products. Food and Drug, 2022, 24(2): 167171.
[4] Zhang Yuzhi. Thoughts and Insights on Antitumor Applications of Traditional Chinese Medicine. Shizhen Traditional Chinese Medicine
and Materia Medica, 2006, 17(8): 1566.
[5] Li Li, Ji Yi, Li Wenting, et al. Advances in Antitumor Research of Traditional Chinese Medicine Based on Autophagy. Journal of Traditional Chinese Medicine, 2019, 34(1): 223225.
[6] Yang Xiaoli, Zhang Junli, Wang Jingfeng, et al. Research Progress on Antitumor Effects and Mechanisms of Chlorogenic Acid. Chinese
Journal of Experimental Traditional Medical Formulae, 2018, 24(19): 229234.
[7] Cao Jian, Wei Runjie, Deng Ruyun, et al. Advances and Perspectives on the Antitumor Mechanisms of Matrine and Oxymatrine. Chinese Traditional and Herbal Drugs, 2019, 50(3): 753760.
[8] Ke Xiaoying, Yu Mengxue, Jiang Ming, et al. Clinical Observation on Sinomenine for Treatment of Rheumatoid Arthritis. Beijing Medical Journal, 1986, 8(3): 186187.
[9] Kang Linzhi, Zhu Dacheng, Liu Zhenshuai. Research Status of Antitumor Mechanisms of Sinomenine. Journal of Traditional Chinese
Medicine, 2023, 41(9): 184188.
[10] Zheng X, Li W, Xu H, et al. Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway. Acta Pharm Sin B. 2021;11(11):3465-3480.
[11] Gao X, Sun B, Hou Y, et al. Anti-breast cancer sinomenine derivatives via mechanisms of apoptosis induction and metastasis reduction.
J Enzyme Inhib Med Chem. 2022;37(1):1870-1883.
[12] Gao X, Li H, Wang S, et al. Discovery of sinomenine/8-Bis(benzylthio)octanoic acid hybrids as potential anti-leukemia drug candidate
via mitochondrial pathway. Bioorg Med Chem Lett. 2024;97:129545.
[13] Zhu L, Chen C, Cai Y, et al. Identification of a ferritinophagy inducer via sinomenine modification for the treatment of colorectal cancer.
Eur J Med Chem. 2024;268:116250.
[14] Cai Zhaoning. Synthesis and Antitumor Activity of A-Ring-Modified Sinomenine Derivatives [D]. Dalian University of Technology, 2023.
[15] Li S, Gao M, Nian X, et al. Design, Synthesis, Biological Evaluation and Silico Prediction of Novel Sinomenine Derivatives. Molecules.
2021;26(11):3466.
[16] Liu Yu. Synthesis of Sinomenine Derivatives and Their Antimelanoma Activity [D]. 2024.
[17] Wei CJ, Xu F, Shi MJ, et al. Synthesis and antitumor activities of sinomenine derivatives on rings A and C. J Asian Nat Prod Res.
2018;20(3):277-291.
[18] Zhu Z, Zhou H, Chen F, et al. Sinomenine Derivatives: Synthesis, Antitumor Activity, and Apoptotic Induction in MCF-7 Cells via IL-6/
PI3K/Akt/NF-?B Signaling Pathway. ChemMedChem. 2022;17(14): e202200234.
[19] Zhou Huixian, Yu Zikai, Wu Zhiwen, et al. Synthesis and In Vitro Antitumor Screening of SinomenineNitrate Ester Conjugates. Chinese Journal of New Drugs, 2024, 33(07): 705713.
[20] Wang Y, Wu L, Cai H, et al. YL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells. Cell Death Discov.
2018;4:44.
[21] Shan H, Cao Y, Xiao X, et al. YL064 activates proteasomal-dependent degradation of c-Myc and synergistically enhances the anti-tumor
activity of ABT-199 in diffuse large B cell lymphoma. Signal Transduct Target Ther. 2020;5(1):116.
[22] Ju Shenaonan, Wang Yingying, Tang Yong, et al. Experimental Study on the Regulation of Chemokine Receptors in Multiple Myeloma
Cells by Sinomenine Derivatives. Chinese Journal of Cancer, 2023, 33(06): 589596.
DOI: http://dx.doi.org/10.70711/mhr.v2i7.7445
Refbacks
- There are currently no refbacks.
