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Advances in Drug Therapy for HER2-positive Advanced Breast Carcinoma

Chuan Su

Abstract


Breast cancer is common in Chinese women, and HER2 positive breast cancer is the most challenging and heterogeneous subtype.
About 20% of breast cancer patients have HER2 gene overexpression, which usually shows strong invasion and high recurrence risk. Although HER2 targeted therapy has significantly improved patient prognosis, drug resistance remains a significant challenge in clinical treatment. In recent years, with the continuous development of targeted drugs, the application of new drugs has brought new hope for the treatment
of HER2 positive advanced breast cancer patients. This paper will focus on the current progress of drug therapy for HER2 positive advanced
breast cancer, and analyze the mechanism, clinical efficacy and potential in the treatment of new drugs.

Keywords


HER2 positive breast cancer; Targeted drugs; Antibody conjugated drugs; Tyrosine kinase inhibitor

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References


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breast cancer [J]. Chinese Journal of Cancer Clinical Sciences, 2025, 52 (02): 97-101.

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breast cancer [J]. Chinese Journal of Cancer, 2024, 33 (07): 583-595.

[3] SwainSM, MilesD, Kim SB, et al. Pertuzumab, trastuzumab, and docetaxel for HER2-positive-metastatic breast cancer (CLEOPATRA):

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[D]. Hebei Medical University, 2024.

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growth factor receptor 2 positive breast cancer [D]. Jilin University, 2021.




DOI: http://dx.doi.org/10.70711/mhr.v2i7.7446

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