Clinical Study of Mini-punch Transplantation Combined with NB-UVB in the Treatment of Refractory Vitiligo
Abstract
therapeutic effect in patients with refractory vitiligo. Methods: A total of 108 patients with refractory vitiligo admitted to our hospital from
May 2022 to May 2024 were selected and randomly divided into three groups, with 36 patients in each group. Patients in experimental group
1 were treated with Mini-punch transplantation combined with NB-UVB, patients in experimental group 2 were treated with Mini-punch
transplantation, and patients in the control group were only treated with epidermal transplantation by negative pressure suction blister method. Before and after treatment, all patients were evaluated using the Vitiligo Area Scoring Index(VASI), and the Dermatology Life Quality
Index(DLQI)scores were statistically analyzed to determine the curative effect and compare the adverse reactions. Results: At the 13th week
after treatment, the total effective rate of experimental group 1 was 77.78%, that of experimental group 2 was 61.11%, and that of the control group was 41.67%. There were significant differences in the total effective rates among the three groups(P<0.05). At the 13th week after
treatment, the VASI scores of all three groups decreased(P<0.05), and there were significant differences in the VASI scores among the three
groups at the 13th week after treatment(P<0.05). At the 13th week after treatment, the DLQI scores of all three groups decreased(P<0.05),
and there were significant differences in the DLQI scores among the three groups(P<0.05). There were significant differences in adverse reactions among the three groups(P<0.05). Conclusion: Mini-punch transplantation combined with NB-UVB has achieved satisfactory results in
the treatment of refractory vitiligo. It can significantly reduce the area of white patches, improve skin lesions, and has few adverse reactions,
which is worthy of promotion.
Keywords
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DOI: http://dx.doi.org/10.70711/mhr.v2i8.8022
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