Advances in Construction of Surface Molecularly Imprinted Materials and Their Efficient Mass Transfer Regulation for Proteins
Abstract
food industry, and clinical diagnostics. Molecular imprinting technology (MIT), which mimics antibody-antigen specific recognition, can produce "artificial antibody" materials with predetermined recognition ability, showing great potential for protein separation. However, traditional
bulk imprinting suffers from high mass transfer resistance, difficult template removal, and poor accessibility of recognition sites, limiting its
application for macromolecular proteins. Surface molecular imprinting technology (SMIT) confines imprinted sites to the surface or near-surface region, fundamentally overcoming mass transfer issues and becoming the mainstream approach. This review systematically summarizes
construction strategies of surface imprinted materials and their regulation mechanisms on protein mass transfer, focusing on key technologies
such as core-shell structure design, ultrathin imprinted layer fabrication, hierarchical pore construction, and oriented template immobilization.
Recent advances in smart responsive imprinted materials and multiscale composite supports for mass transfer optimization are also summarized. Finally, current challenges and future directions are discussed, aiming to provide a theoretical reference for designing high-performance
protein separation materials.
Keywords
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[1] C. G. A. Maria, A. Varghese, M. Nidhin, "Recent Advances in Nanomaterials Based Molecularly Imprinted Electrochemical Sensors, "
Critical Reviews in Analytical Chemistry 53, no. 1 (2023): 88-97.
[2] E. K. Reville, E. H. Sylvester, S. J. Benware, S. S. Negi, E. B. Berda, "Customizable molecular recognition: advancements in design,
synthesis, and application of molecularly imprinted polymers, " Polymer Chemistry 13, no. 23 (2022): 3387-3411.
[3] Y. F. Zhang, H. Q. Zhang, L. Q. Shi, "Progress in the preparation of advanced molecularly imprinted polymers via surface templateanchoring methods, " Trac-Trends in Analytical Chemistry 195, no. (2026): 118591.
[4] Z. P. Liu, A. J. Gong, L. N. Qiu, et al., "Advances in high abundance protein molecular imprinting techniques in human serum, " Australian Journal of Chemistry 76, no. 3 (2023): 150-168.
[5] A. Kausar, "Molecularly Imprinted Polymers and Nanocomposites-Essentials Features and Applied Versatilities, " Polymer-Plastics
Technology and Materials 64, no. 8 (2025): 1101-1129.
[6] Y. B. Hua, D. Kukkar, R. J. C. Brown, K. H. Kim, "Recent advances in the synthesis of and sensing applications for metal-organic
framework-molecularly imprinted polymer (MOF-MIP) composites, " Critical Reviews in Environmental Science and Technology 53,
no. 2 (2023): 258-289.
[7] Y. Y. Wan, C. Liu, S. T. Wang, et al., "Molecularly imprinted framework materials: design, synthesis, applications, and perspectives, "
Coordination Chemistry Reviews 547, no. (2026): 35.
[8] Q. M. Song, K. V. Van, X. H. Li, Z. M. Chen, Y. Q. Lv, "Molecularly Imprinted Membranes for Selective Biomarker Recognition: Recent Advances and Emerging Strategies, " Chem & Bio Engineering 2, no. 12 (2025): 713-738.
[9] H. A. El-Sabban, I. S. Gataa, M. A. Diab, et al., "Recent progress in antigenic determinants with antibody substitutes via epitope imprinting: Innovative approaches, practical applications, and computational strategies, " Microchemical Journal 220, no. (2026): 22.
[10] R. Keili, G. Hussain, C. M. Hussain, A. Denizli, "Eco-friendly molecularly imprinted polymer-based sensing platforms towards pharmaceuticals: recent advances and future prospects, " Talanta Open 11, no. (2025): 100446.
[11] Y. H. Zhang, Y. P. Zhu, L. S. Loo, J. G. Yin, K. A. Wang, "Synthesizing molecularly imprinted polymer beads for the purification of vitamin E, " Particuology 57, no. (2021): 10-18.
[12] S. Ashraf, G. Mustafa, K. Pervaiz, A. A. Altaf, M. Hamayun, "Smart recognition of chemical contaminants in food: experimental and
computational perspectives on MIP-based sensors, " Analytical Methods 18, no. 5 (2026): 973-996.
[13] Q. M. Song, X. H. Li, Y. Lyu, "Design and synthesis of molecularly imprinted polymers and their applications in medical diagnosis and
biocatalysis, " Chinese Journal of Chromatography 44, no. 2 (2026): 134-150.
[14] Y. N. Li, C. J. Guan, C. R. Liu, Z. Li, G. H. Han, "Disease diagnosis and application analysis of molecularly imprinted polymers (MIPs)
in saliva detection, " Talanta 269, no. (2024): 125394.
DOI: http://dx.doi.org/10.70711/frim.v4i6.9703
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