pisco_log
banner

Optimization the Preparation Process of Paeonia lactiflora Based on Effective Components and Contents

Shushuang Shen, Biyue Cui, Liting Mu, Xinran Zhang, Changhai Sun*

Abstract


To optimize the multi-component collaborative extraction process of Paeonia lactiflora roots, the Analytic Hierarchy Process
(AHP) was used to determine weight coefficients of eight effective components, and a multi-index evaluation system was established using a
weighted comprehensive scoring method. Single-factor experiments screened the optimal ranges of material-liquid ratio, ultrasonic time, and
ethanol concentration, followed by star-point design response surface methodology for three-factor optimization. The quadratic polynomial
model fit well (R²=0.8198). Optimal parameters: solid-liquid ratio 1:25 g/mL, ultrasonic time 69 min, ethanol concentration 83%, with a
predicted comprehensive score of 90.9. Three validation experiments averaged 90.8 (RSD=0.38%), deviation of 0.30%, confirming high
model reliability. This method combines AHP weights with response surface methodology, overcoming single-indicator limitations and
improving extraction efficiency and stability.

Keywords


Paeonia lactiflora; Active Ingredient; Content; Response Surface Method; Process Optimization

Full Text:

PDF

Included Database


References


[1] Nanjing University of Chinese Medicine. Dictionary of Chinese Materia Medica. Shanghai: Shanghai Science and Technology Press,

2006: 946, 1438.

[2] Wang R. Study on chemical constituents of Paeonia veitchii and quality control methods of Paeonia lactiflora [D]. Shenyang: Shenyang

Pharmaceutical University, 2005.

[3] Wang J. Study on the effect of white peony root extract on raccoon dog production performance and anti-enteritis mechanism [D]. Beijing: Chinese Academy of Agricultural Sciences, 2021.

[4] Zhao W. Application of peony seed oil/meal and paeoniflorin in grass carp feed [D]. Henan: Henan Normal University, 2023.

[5] Liu A, et al. Effect of microwave processing on quality of Ziziphi Spinosae Semen based on AHP and multi-index evaluation. J Chin

Med Mater, 2018, 41(1):84-88.

[6] Li H, et al. Optimization of wine-stewing processing technology of Ligustri Lucidi Fructus based on AHP and multi-index orthogonal

test. Chin Tradit Herb Drugs, 2016, 47(16):2832-2837.

[7] Zhang L, et al. Optimization of alcohol-water extraction process of Chaenomeles speciosa by multi-index orthogonal test based on AHP

scoring. West China J Pharm Sci, 2017, 32(2):189-192.

[8] Zha R, et al. Multi-index comprehensive evaluation for extraction method optimization of Chaenomeles speciosa based on AHP. Chin

Tradit Pat Med, 2014, 36(3):643-646.

[9] Pablo AB, et al. An AHP/ANP-based multi-criteria decision approach for solar-thermal power plant investment projects. Energy, 2014,

66(1):222-238.

[10] Thomas K. Application of AHP to evaluate regional sustainability of bioenergy developments. Energy, 2013, 62(1):393-402.

[11] Deng X, et al. Analysis and application of weight calculation methods in AHP. Math Pract Theory, 2012, 42(7):93-100.

[12] Zhou Y, et al. Evaluation of important medicinal plant resources in Qinling Mountains based on AHP. Chin Tradit Herb Drugs, 2013,

44(15):2172-2182.

[13] Li J, et al. Optimization of feed formula for Poecilobdella manillensis by orthogonal test. Chin Tradit Herb Drugs, 2014, 45(6):782-785.

[14] Yang L, et al. Comprehensive evaluation of introduced peony value based on AHP. Mod Hortic, 2023, (1):87-88.

[15] Xu Z, et al. Multi-index evaluation of bran-fried Paeonia lactiflora processing technology. Chin Tradit Herb Drugs, 2014,

45(13):1867-1870.

[16] Gu Z, et al. Optimization of smoking processing technology of Angelica sinensis based on AHP and BPNN combined model. Chin J

New Drugs, 2014, 23(22):2664-2670.

[17] Han X, et al. Research progress on pharmacological effects and mechanisms of salidroside. Chin J Biochem Pharm, 2015,

35(1):171-175.

[18] Zhang X, et al. Effect of stewing time on salidroside content in Ligustri Lucidi Fructus. Mod Chin Med, 2009, 11(4):35-37.

[19] Yang G, et al. HPLC fingerprint of raw and processed Ligustri Lucidi Fructus. Chin Tradit Herb Drugs, 2016, 47(5):760‑766.

[20] Xiao W, et al. Effects of different processing methods on chemical constituents of Ligustri Lucidi Fructus. Chin J Inf Tradit Chin Med,

2015, 22(7):82-84.

[21] Zhao Z, et al. Content variation of two triterpenoids and water-soluble low-molecular-weight sugars during processing of Ligustri Lucidi Fructus. Liaoning J Tradit Chin Med, 2012, 39(12):2454-2457.

[22] Zeng L, Xia Z. Promotion and influence of ultrasound and microwave on extraction of Chinese medicinal materials. Chem Res Appl,

2002, 14(3):245.




DOI: http://dx.doi.org/10.70711/frim.v4i7.9860

Refbacks

  • There are currently no refbacks.